4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-

Base Information

Chemical Name:4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-
CAS No.:1142946-16-4
Molecular Formula:C17H20N6O
Molecular Weight:324.385
Hs Code.:2933990090
Mol file:1142946-16-4.mol

Synonyms:4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-

Suppliers and Price of 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-((4-(4-Methylpiperazin-1-yl)phenyl)amino)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one 95+%
1g
$ 987.00

Chemenu
2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one 95%
1g
$ 931.00

American Custom Chemicals Corporation
2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-OL 95.00%
5MG
$ 500.94

Total 7 raw suppliers

Chemical Property of 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-

Chemical Property:

PSA：80.31000
LogP:2.23480
Storage Temp.:2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-((4-(4-Methylpiperazin-1-yl)phenyl)amino)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-

There total 2 articles about 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52133-67-2
ethyl 2-cyano-4,4-diethoxybutyrate

: 1143571-97-4
(Z)-tert-butyl (tert-butoxycarbonylamino)(4-(4-methylpiperazin-1-yl)phenylamino)methylenecarbamate

: 1142946-16-4
2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ol

Guidance literature:: (Z)-tert-butyl (tert-butoxycarbonylamino)(4-(4-methylpiperazin-1-yl)phenylamino)methylenecarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 17h;

ethyl 2-cyano-4,4-diethoxybutyrate; With sodium methylate; In methanol; ethanol; at 160 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; ammonium hydroxide; more than 3 stages;

Reference yield:

: 16153-81-4
4-(4-Methyl-piperazino)-anilin

: 1142946-16-4
2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 17 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C

2.2: 0.5 h / 160 °C / Microwave irradiation

With trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield: 69.0%

: 1142946-16-4
2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ol

: 1142946-17-5
⁽⁰⁸¹⁾C₀₇₅₀₅

Guidance literature:: 2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ol; With trichlorophosphate; at 120 ℃; for 0.333333h;

With sodium hydroxide; In water; at 0 ℃; pH=9 - 10;