1-Propanone, 1-(2-benzofuranyl)-

Base Information

• Chemical Name: 1-Propanone, 1-(2-benzofuranyl)-
• CAS No.: 91344-52-4
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.199
• Mol file: 91344-52-4.mol

Synonyms:2-Propanoylbenzofuran;1-(2-BENZOFURANYL)-1-PROPANONE;1-(Benzofuran-2-yl)-1-propanone;1-PROPANONE, 1-(2-BENZOFURANYL)-;

Chemical Property of 1-Propanone, 1-(2-benzofuranyl)-

Chemical Property:

• PSA: 30.21000
• LogP: 3.02550

Purity/Quality:

97% ^*data from raw suppliers

1-(2-benzofuranyl)-1-Propanone 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Propanone, 1-(2-benzofuranyl)-

There total 8 articles about 1-Propanone, 1-(2-benzofuranyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(benzofuran-2-yl)trimethylsilane (60981-57-9) + propionyl chloride (79-03-8) → 1-(2-benzofuranyl)-1-propanone (91344-52-4)

Guidance literature:

titanium tetrachloride; In dichloromethane; at -78 ℃; for 0.0833333h;

DOI:10.1016/0040-4020(84)85067-X

Reference yield: 69.6%

2-methyl-benzyl alcohol (89-95-2) + 1-Bromo-2-butanone (816-40-0) → 1-(2-benzofuranyl)-1-propanone (91344-52-4)

Guidance literature:

With sodium methylate; sodium hydride; In N,N-dimethyl-formamide; at 110 - 120 ℃; for 2h;

DOI:10.1111/j.2042-7158.1998.tb03352.x

Reference yield: 68.0%

1-(benzo[b]furan-2-yl)ethanone (1646-26-0) + methyl iodide (74-88-4) → 1-(2-benzofuranyl)-1-propanone (91344-52-4)

Guidance literature:

1-(benzo[b]furan-2-yl)ethanone; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; for 24h;

DOI:10.5012/bkcs.2012.33.10.3497

upstream raw materials:

benzofuran-2-carbonitrile

ethylmagnesium bromide

1-(benzofuran-2-yl)propan-1-ol

(benzofuran-2-yl)trimethylsilane

Downstream raw materials:

3-(2'-benzofuranyl)-2,2-dimethylpentanoic acid