Pyrrolidine, 1-(2-methoxyphenyl)-

Base Information

• Chemical Name: Pyrrolidine, 1-(2-methoxyphenyl)-
• CAS No.: 4787-76-2
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Mol file: 4787-76-2.mol

Synonyms:PYRROLIDINE, 1-(2-METHOXYPHENYL)-;1-(2-METHOXYPHENYL)-PYRROLIDINE;

Chemical Property of Pyrrolidine, 1-(2-methoxyphenyl)-

Chemical Property:

• PSA: 12.47000
• LogP: 2.36040

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolidine, 1-(2-methoxyphenyl)-

There total 11 articles about Pyrrolidine, 1-(2-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyrrolidine (123-75-1) + 2-bromoanisole (578-57-4) → 1-(2-methoxyphenyl)pyrrolidine (4787-76-2)

Guidance literature:

With potassium phosphate; copper(l) iodide; CVT-2537; In dimethyl sulfoxide; at 90 ℃; Inert atmosphere;

DOI:10.1021/ol301135c

Reference yield: 94.0%

pyrrolidine (123-75-1) + 2-Chloroanisole (766-51-8) → 1-(2-methoxyphenyl)pyrrolidine (4787-76-2)

Guidance literature:

With [Pd(2-aminobiphenyl)(PCyp₂Ar^Xyl₂)](OMs); sodium t-butanolate; In tetrahydrofuran; at 80 ℃; for 19h; Reagent/catalyst; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201903279

Reference yield: 85.0%

butanedial (638-37-9) + 2-methoxy-phenylamine (90-04-0) → 1-(2-methoxyphenyl)pyrrolidine (4787-76-2)

Guidance literature:

With potassium hydroxide; iron pentacarbonyl; carbon monoxide; In ethanol; water; for 20h; Ambient temperature;

DOI:10.1016/S0040-4020(01)87426-3

upstream raw materials:

1,4-dibromo-butane

2-methoxy-phenylamine

pyrrolidine

1,2-dimethoxybenzene

Downstream raw materials:

1-(2-dimethylcarbamoyloxy-phenyl)-1-methyl-pyrrolidinium; iodide

dimethyl-carbamic acid-(2-pyrrolidino-phenyl ester)

2-(pyrrolidin-1-yl)phenol

Refernces

• 1、 Yi, Ming-Jun,Xiao, Teng-Fei,Li, Wen-Hui,Zhang, Yi-Fan,Yan, Pen-Ji,Zhang, Baoxin,Xu, Peng-Fei,Xu, Guo-Qiang. "Organic photoredox catalytic α-C(sp3)-H phosphorylation of saturated: Aza -heterocycles". supporting information. p. 13158 - 13161. Retrieved 2021/12/16.
• 2、 -. "Tropane alkaloid compounds and method of manufacturing using sequential oxidation reactions". Paragraph 0098; 0104-0108. . Retrieved 2020/06/16.