5(4H)-Oxazolone, 2-methyl-4-[(3-methylphenyl)methylene]-

Base Information

• Chemical Name: 5(4H)-Oxazolone, 2-methyl-4-[(3-methylphenyl)methylene]-
• CAS No.: 78311-97-4
• Molecular Formula: C12H11NO2
• Molecular Weight: 201.22
• Mol file: 78311-97-4.mol

Synonyms:2-METHYL-4-[(3-METHYLPHENYL)METHYLENE]-5(4H)-OXAZOLONE;5(4H)-OXAZOLONE, 2-METHYL-4-[(3-METHYLPHENYL)METHYLENE]-;

Chemical Property of 5(4H)-Oxazolone, 2-methyl-4-[(3-methylphenyl)methylene]-

Chemical Property:

• PSA: 38.66000
• LogP: 1.74670

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5(4H)-Oxazolone, 2-methyl-4-[(3-methylphenyl)methylene]-

There total 1 articles about 5(4H)-Oxazolone, 2-methyl-4-[(3-methylphenyl)methylene]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

m-tolyl aldehyde (620-23-5) + N-acetylglycine (543-24-8) → 4-(3-methylphenyl)methylene-2-methyl-5(4H)-oxazolone (78311-97-4)

Guidance literature:

With sodium acetate; acetic anhydride; Inert atmosphere; Microwave irradiation;

DOI:10.1007/s00044-012-0190-z

Reference yield: 64.0%

4-(3-methylphenyl)methylene-2-methyl-5(4H)-oxazolone (78311-97-4) + p-aminobenzophenone (99-92-3) → 1-(4-acetylphenyl)-2-methyl-4-(3-methylbenzylidene)-1H-imidazol-5(4H)-one (1394856-49-5)

Guidance literature:

With sodium acetate; acetic acid; Microwave irradiation; Inert atmosphere;

DOI:10.1007/s00044-012-0190-z

Reference yield:

4-(3-methylphenyl)methylene-2-methyl-5(4H)-oxazolone (78311-97-4) → 2-(1-(4-(2-methyl-4-(3-methylbenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl)phenyl)ethylidene)hydrazinecarbothioamide (1394856-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate; acetic acid / Microwave irradiation; Inert atmosphere

2: N,N-dimethyl-formamide / Inert atmosphere; Microwave irradiation

With sodium acetate; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1007/s00044-012-0190-z

upstream raw materials:

m-tolyl aldehyde

N-acetylglycine

Downstream raw materials:

2-(1-(4-(2-methyl-4-(3-methylbenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl)phenyl)ethylidene)hydrazinecarbothioamide

2-((1-(4-(2-methyl-4-(3-methylbenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl)phenyl)ethylidene)hydrazono)thiazolidin-4-one

1-(4-acetylphenyl)-2-methyl-4-(3-methylbenzylidene)-1H-imidazol-5(4H)-one

(Z)-2-hydroxy-3-m-tolyl-acrylic acid