6270-06-0

Basic information

• Product Name: N-(2-CHLOROETHYL)PHTHALIMIDE
• Synonyms: N-(B-CHLOROETHYL)PHTHALIMIDE;N-(2-CHLOROETHYL)PHTHALIMIDE;AKOS BB-8696;2-(2-CHLOROETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE;N-(2-CHLOROETHYL)PHTHALIMIDE, 98+%;2-(2-Chloroethyl)-;2-(2-chloroethyl)isoindole-1,3-dione;2-(2-chloroethyl)isoindoline-1,3-dione
• CAS NO: 6270-06-0
• Molecular Formula: C₁₀H₈ClNO₂
• Molecular Weight: 209.63
• Product Categories: Carbonyl Compounds;Cyclic Imides;Organic Building Blocks;Aromatics;Heterocycles
• Mol File: 6270-06-0.mol

Chemical Properties

• Melting Point: 82-84 °C(lit.)
• Boiling Point: 328.2 °C at 760 mmHg
• Flash Point: 152.3 °C
• Appearance: /
• Density: 1.383 g/cm³
• Vapor Pressure: 0.000192mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Refrigerator
• PKA: -2.32±0.20(Predicted)
• CAS DataBase Reference: N-(2-CHLOROETHYL)PHTHALIMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-CHLOROETHYL)PHTHALIMIDE(6270-06-0)
• EPA Substance Registry System: N-(2-CHLOROETHYL)PHTHALIMIDE(6270-06-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 6270-06-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-(2-Chloroethyl)phthalimide is used as a key intermediate in the synthesis of 1-[(dialkylamino)alkyl]-1,8-naphthyridin-2(1H)ones, which are evaluated for their ability to inhibit gastric acid secretion in vivo. This application is significant in the development of medications aimed at treating conditions related to excessive gastric acid production, such as peptic ulcers and gastroesophageal reflux disease (GERD).

InChI:InChI=1/C10H8ClNO2/c11-5-6-12-9(13)7-3-1-2-4-8(7)10(12)14/h1-4H,5-6H2

Upstream product

• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 98-88-4 benzoyl chloride 
• 85-44-9 phthalic anhydride 
• 80-41-1 2-chloroethyl tosylate 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 88-99-3 benzene-1,2-dicarboxylic acid 
• 689-98-5 chloroethylamine 
• 7501-05-5 N-(2-phenylethyl)phthalimide 
• 41010-04-2 4-nitro-2-(2-(phenylthio)ethyl)isoindoline-1,3-dione 
• 52096-63-6 2-<2-(Benzylthio)ethyl>-1H-isoindole-1,3(2H)-dione 
• 863393-70-8 3-hydroxy-2-[(2-phenylthio)ethyl]-2,3-dihydro-1H-isoindol-1-one 
• 1204757-06-1 2-(2-((Z)-5-(3-fluorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)ethyl)isoindoline-1,3-dione 
• 30250-66-9 2-(2-azidoethyl)isoindoline-1,3-dione 
• 41575-23-9 2-(2-chloroethyl)-1-isoindolinone 

Relevant articles and documents

Delta-aminoalkylbenzofuranol ethers, and preparation method and application thereof

The invention relates to delta-aminoalkylbenzofuranol ethers represented by chemical structural formula I shown in the description, and an application thereof in the preparation of herbicides. In thechemical structural formula I, R is selected from C1-C2 alkyl groups, and n is selected from 2, 3 and 4.

Nucleophilic Substitutions of Alcohols in High Levels of Catalytic Efficiency

A practical method for the nucleophilic substitution (SN) of alcohols furnishing alkyl chlorides, bromides, and iodides under stereochemical inversion in high catalytic efficacy is introduced. The fusion of diethylcyclopropenone as a simple Lewis base organocatalyst and benzoyl chloride as a reagent allows notable turnover numbers up to 100. Moreover, the use of plain acetyl chloride as a stoichiometric promotor in an invertive SN-type transformation is demonstrated for the first time. The operationally straightforward protocol exhibits high levels of stereoselectivity and scalability and tolerates a variety of functional groups.