5-AMino-2-Methyl-piperidine-1-carboxylic acid benzyl ester

Base Information

• Chemical Name: 5-AMino-2-Methyl-piperidine-1-carboxylic acid benzyl ester
• CAS No.: 1207947-49-6
• Molecular Formula: C14H20N2O2
• Molecular Weight: 248.32
• Mol file: 1207947-49-6.mol

Synonyms:5-AMino-2-Methyl-piperidine-1-carboxylic acid benzyl ester

Chemical Property of 5-AMino-2-Methyl-piperidine-1-carboxylic acid benzyl ester

Chemical Property:

• Boiling Point: 373.2±42.0 °C(Predicted)
• PKA: 10.34±0.40(Predicted)
• PSA: 55.56000
• Density: 1.111±0.06 g/cm3(Predicted)
• LogP: 2.77300

Purity/Quality:

99%, ^*data from raw suppliers

benzyl(2S,5R)-5-amino-2-methylpiperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMino-2-Methyl-piperidine-1-carboxylic acid benzyl ester

There total 17 articles about 5-AMino-2-Methyl-piperidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzyl 5-((tert-butoxycarbonyl)amino)-2-methylpiperidine-1-carboxylate → benzyl 5-amino-2-methyl-piperidine-1-carboxylate (1207947-49-6)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

(2R,5R)-benzyl 5-azido-2-methylpiperidine-1-carboxylate (1612786-30-7) → benzyl (2R,5R)-5-amino-2-methyl-piperidine-1-carboxylate (1207853-72-2,1207947-49-6)

Guidance literature:

With trimethylphosphane; In tetrahydrofuran; toluene; for 0.333333h;

Reference yield:

rac-(2S,5S)-benzyl 5-((tert-butoxycarbonyl)amino)-2-methylpiperidine-1-carboxylate → benzyl (2R,5R)-5-amino-2-methyl-piperidine-1-carboxylate (1207853-72-2,1207947-49-6) + benzyl (2S,5S)-5-amino-2-methyl-piperidine-1-carboxylate (1207947-49-6)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 15 ℃; for 1h;

upstream raw materials:

(2R,5S)-benzyl 2-methyl-5-((methylsulfonyl)oxy)piperidine-1-carboxylate

(2R,5S)-benzyl 5-hydroxy-2-methylpiperidine-1-carboxylate

(2R,5R)-benzyl 5-azido-2-methylpiperidine-1-carboxylate

benzyl chloroformate

Downstream raw materials:

(2R,5R)-benzyl 2-methyl-5-(6-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)pyrazin-2-ylamino)piperidine-1-carboxylate

tert-butyl ((3R,6R)-6-methylpiperidin-3-yl)carbamate

tert-butyl ((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)carbamate

(2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-amino-2-methylpiperidin-1-yl)methanone

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