(2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-amino-2-methylpiperidin-1-yl)methanone

Base Information

Chemical Name:(2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-amino-2-methylpiperidin-1-yl)methanone
CAS No.:1612786-54-5
Molecular Formula:C₁₅H₁₉N₅O
Molecular Weight:285.349
Hs Code.:

Synonyms:(2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-amino-2-methylpiperidin-1-yl)methanone

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Chemical Property of (2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-amino-2-methylpiperidin-1-yl)methanone

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Technology Process of (2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-amino-2-methylpiperidin-1-yl)methanone

There total 11 articles about (2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-amino-2-methylpiperidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-azido-2-methylpiperidin-1-yl)methanone

: 1612786-54-5
(2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-amino-2-methylpiperidin-1-yl)methanone

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 4h; under 1034.32 Torr;

Reference yield:

: 1612786-33-0
tert-butyl ((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)carbamate

: 1612786-54-5
(2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-amino-2-methylpiperidin-1-yl)methanone

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 2h;

Reference yield:

: 1431473-24-3
(2R,5S)-benzyl 5-hydroxy-2-methylpiperidine-1-carboxylate

: 1612786-54-5
(2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-amino-2-methylpiperidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 °C

2: sodium azide / N,N-dimethyl-formamide / 85 °C

3: trimethylphosphane / tetrahydrofuran; toluene / 0.33 h

4: dmap / dichloromethane / 20 °C

5: palladium 10% on activated carbon; hydrogen / ethanol; methanol / 20 °C

6: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

7: hydrogenchloride / ethyl acetate / 2 h

With hydrogenchloride; dmap; sodium azide; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trimethylphosphane; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;