(2R,5S)-benzyl 2-methyl-5-((methylsulfonyl)oxy)piperidine-1-carboxylate

Base Information

Chemical Name:(2R,5S)-benzyl 2-methyl-5-((methylsulfonyl)oxy)piperidine-1-carboxylate
CAS No.:1612786-29-4
Molecular Formula:C₁₅H₂₁NO₅S
Molecular Weight:327.401
Hs Code.:

Synonyms:(2R,5S)-benzyl 2-methyl-5-((methylsulfonyl)oxy)piperidine-1-carboxylate

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Chemical Property of (2R,5S)-benzyl 2-methyl-5-((methylsulfonyl)oxy)piperidine-1-carboxylate

Chemical Property:

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Technology Process of (2R,5S)-benzyl 2-methyl-5-((methylsulfonyl)oxy)piperidine-1-carboxylate

There total 11 articles about (2R,5S)-benzyl 2-methyl-5-((methylsulfonyl)oxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431473-24-3
(2R,5S)-benzyl 5-hydroxy-2-methylpiperidine-1-carboxylate

: 124-63-0
methanesulfonyl chloride

: 1612786-29-4
(2R,5S)-benzyl 2-methyl-5-((methylsulfonyl)oxy)piperidine-1-carboxylate

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

: 1314395-91-9
(±)-benzyl 2-methyl-5-oxopiperidine-1-carboxylate

: 1612786-29-4
(2R,5S)-benzyl 2-methyl-5-((methylsulfonyl)oxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium borohydride / methanol; tetrahydrofuran / 0.5 h / -10 - -5 °C

2: SFC, IC 30x250mm / methanol / Resolution of racemate

3: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 °C

With dmap; lithium borohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1121-78-4
5-Hydroxy-2-methylpyridine

: 1612786-29-4
(2R,5S)-benzyl 2-methyl-5-((methylsulfonyl)oxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; platinum(IV) oxide; hydrogen / methanol / 70 °C / 2585.81 Torr

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C

3.2: -78 - 20 °C

4.1: lithium borohydride / methanol; tetrahydrofuran / 0.5 h / -10 - -5 °C

5.1: SFC, IC 30x250mm / methanol / Resolution of racemate

6.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 °C

With hydrogenchloride; dmap; platinum(IV) oxide; lithium borohydride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;