2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile

Base Information

Chemical Name:2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile
CAS No.:1612786-14-7
Molecular Formula:C₂₁H₂₁N₇O
Molecular Weight:387.444
Hs Code.:

Synonyms:2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile

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Chemical Property of 2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile

Chemical Property:

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Technology Process of 2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile

There total 8 articles about 2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1612786-54-5
(2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-amino-2-methylpiperidin-1-yl)methanone

: 3939-14-8
2-fluoropyridine-4-carbonitrile

: 1612786-14-7
2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile

Guidance literature:: With caesium carbonate; In dimethyl sulfoxide; at 50 ℃; for 48h;

Reference yield:

: 1207853-22-2
(2R,5R)-benzyl-5-((tert-butoxycarbonyl)amino-2-methyl)piperidine-1-carboxylate

: 1612786-14-7
2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / ethanol; methanol / 20 °C

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

3: hydrogenchloride / ethyl acetate / 2 h

4: caesium carbonate / dimethyl sulfoxide / 48 h / 50 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1612786-29-4
(2R,5S)-benzyl 2-methyl-5-((methylsulfonyl)oxy)piperidine-1-carboxylate

: 1612786-14-7
2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: sodium azide / N,N-dimethyl-formamide / 85 °C

2: trimethylphosphane / tetrahydrofuran; toluene / 0.33 h

3: dmap / dichloromethane / 20 °C

4: palladium 10% on activated carbon; hydrogen / ethanol; methanol / 20 °C

5: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

6: hydrogenchloride / ethyl acetate / 2 h

7: caesium carbonate / dimethyl sulfoxide / 48 h / 50 °C

With hydrogenchloride; dmap; sodium azide; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trimethylphosphane; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;