2-(5-Chloro-2-hydroxybenzyl)thiazole-4-carboxylic acid

Base Information

Chemical Name:2-(5-Chloro-2-hydroxybenzyl)thiazole-4-carboxylic acid
CAS No.:913650-33-6
Molecular Formula:C₁₁H₈ClNO₃S
Molecular Weight:269.708
Hs Code.:

Synonyms:

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Chemical Property of 2-(5-Chloro-2-hydroxybenzyl)thiazole-4-carboxylic acid

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 2-(5-Chloro-2-hydroxybenzyl)thiazole-4-carboxylic acid

There total 7 articles about 2-(5-Chloro-2-hydroxybenzyl)thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913650-22-3
ethyl 2-((5-chloro-2-[(phenylmethyl)oxy]phenyl)methyl)-1,3-thiazole-4-carboxylate

: 913650-33-6
2-[(5-chloro-2-hydroxyphenyl)methyl]-1,3-thiazole-4-carboxylic acid

Guidance literature:: With sodium thiomethoxide; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

: 149428-98-8
(5-chloro-2-((phenylmethyl)oxy)phenyl)acetic acid

: 913650-33-6
2-[(5-chloro-2-hydroxyphenyl)methyl]-1,3-thiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C

2.1: Lawessons reagent / 1,2-dimethoxyethane / 2 h / 20 °C

3.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h

3.2: 0.02 h

3.3: 1.5 h / 0 - 20 °C

4.1: sodium thiomethoxide / N,N-dimethyl-formamide / 2 h / 100 °C

With Lawessons reagent; 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; potassium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium thiomethoxide; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1450-74-4
5-chloro-2-hydroxyacetophenone

: 913650-33-6
2-[(5-chloro-2-hydroxyphenyl)methyl]-1,3-thiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / 2 h / Heating / reflux

2.1: iodine; silver nitrate / ethanol / 16 h / Heating / reflux

3.1: water / ethanol / 1.5 h / 90 °C

4.1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C

5.1: Lawessons reagent / 1,2-dimethoxyethane / 2 h / 20 °C

6.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h

6.2: 0.02 h

6.3: 1.5 h / 0 - 20 °C

7.1: sodium thiomethoxide / N,N-dimethyl-formamide / 2 h / 100 °C

With Lawessons reagent; 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; water; iodine; potassium carbonate; potassium hydrogencarbonate; silver nitrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium thiomethoxide; In 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide;