N-Boc-D-tyrosine N'-methoxy-N'-methylamide

Base Information

• Chemical Name: N-Boc-D-tyrosine N'-methoxy-N'-methylamide
• CAS No.: 929872-80-0
• Molecular Formula: C16H24N2O5
• Molecular Weight: 324.377
• Mol file: 929872-80-0.mol

Synonyms:N-Boc-D-tyrosine N'-Methoxy-N'-MethylaMide;Carbamic acid, N-[(1R)-1-[(4-hydroxyphenyl)methyl]-2-(methoxymethylamino)-2-oxoethyl]-, 1,1-dimethylethyl ester

Chemical Property of N-Boc-D-tyrosine N'-methoxy-N'-methylamide

Chemical Property:

• Melting Point: 110 - 112 °C
• PSA: 88.10000
• LogP: 2.23870

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Boc-D-tyrosine N'-methoxy-N'-methylamide

There total 1 articles about N-Boc-D-tyrosine N'-methoxy-N'-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(tert-butoxycarbonyl)-D-tyrosine (70642-86-3) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → tert-butyl (R)-3-(4-hydroxyphenyl)-1-[methoxy(methyl)amino]-1-oxopropan-2-ylcarbamate (929872-80-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; under 37.5038 - 75.0075 Torr;

Reference yield: 100.0%

tert-butyl (R)-3-(4-hydroxyphenyl)-1-[methoxy(methyl)amino]-1-oxopropan-2-ylcarbamate (929872-80-0) → C14H19NO4

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃;

Reference yield: 75.0%

tert-butyl (R)-3-(4-hydroxyphenyl)-1-[methoxy(methyl)amino]-1-oxopropan-2-ylcarbamate (929872-80-0) + methyl iodide (74-88-4) → tert-butyl (R)-3-(4-hydroxyphenyl)-1-[methoxy(methyl)amino]-1-oxopropan-2-yl(methyl)carbamate

Guidance literature:

tert-butyl (R)-3-(4-hydroxyphenyl)-1-[methoxy(methyl)amino]-1-oxopropan-2-ylcarbamate; With sodium hydride; In N,N-dimethyl-formamide; at -20 ℃;

methyl iodide; In N,N-dimethyl-formamide; at -20 ℃; for 3h; Further stages.;

DOI:10.1055/s-2006-958931

upstream raw materials:

N-(tert-butoxycarbonyl)-D-tyrosine

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

2-(trimethylsilyl)ethyl (4R)-4-[tert-butoxycarbonyl(methyl)amino]-5-(4-methoxyphenyl)-3-oxopentanoate

C₂₃H₃₅N₃O₆Si

C₁₇H₂₃F₃N₂O₇S

(R)-α-<<(1,1-dimethylethoxy)carbonyl>amino><1,1'-biphenyl>-4-propanal