2-(4-Isopropoxy-3-Methoxyphenyl)acetonitrile

Base Information

• Chemical Name: 2-(4-Isopropoxy-3-Methoxyphenyl)acetonitrile
• CAS No.: 861069-45-6
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.257
• Hs Code.: 2926909090
• Mol file: 861069-45-6.mol

Synonyms:2-(3-methoxy-4-propan-2-yloxyphenyl)acetonitrile;

Chemical Property of 2-(4-Isopropoxy-3-Methoxyphenyl)acetonitrile

Chemical Property:

• PSA: 42.25000
• LogP: 2.54848
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Isopropoxy-3-methoxyphenyl)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Isopropoxy-3-Methoxyphenyl)acetonitrile

There total 5 articles about 2-(4-Isopropoxy-3-Methoxyphenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vanillin (121-33-5,8014-42-4) → vanillin (861069-45-6)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: potassium borohydride / methanol / 20 °C

3: thionyl chloride / dichloromethane / 0 °C

4: acetonitrile / Reflux

With thionyl chloride; potassium borohydride; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.ejmech.2014.08.038

Reference yield:

4-isopropyloxy-3-methoxybenzaldehyde (2538-98-9) → vanillin (861069-45-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium borohydride / methanol / 20 °C

2: thionyl chloride / dichloromethane / 0 °C

3: acetonitrile / Reflux

With thionyl chloride; potassium borohydride; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.ejmech.2014.08.038

Reference yield:

vanillin (2539-22-2) → vanillin (861069-45-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 0 °C

2: acetonitrile / Reflux

With thionyl chloride; In dichloromethane; acetonitrile;

DOI:10.1016/j.ejmech.2014.08.038

upstream raw materials:

sodium cyanide

vanillin

vanillin

4-isopropyloxy-3-methoxybenzaldehyde

Refernces

• 1、 Shen, Li,Yang, Xiaochun,Yang, Bo,He, Qiaojun,Hu, Yongzhou. "Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents". scheme or table. p. 11 - 18. Retrieved 2010/03/03.