4-Isopropoxy-3-methoxybenzyl chloride

Base Information

• Chemical Name: 4-Isopropoxy-3-methoxybenzyl chloride
• CAS No.: 1036588-32-5
• Molecular Formula: C₁₁H₁₅ClO₂
• Molecular Weight: 214.692
• Mol file: 1036588-32-5.mol

Synonyms:4-Isopropoxy-3-Methoxybenzyl chloride;4-(Chloromethyl)-1-isopropoxy-2-methoxybenzene;4-(Chloromethyl)-2-methoxy-1-(1-methylethoxy)benzene;Benzene, 4-(chloromethyl)-2-methoxy-1-(1-methylethoxy)-

Chemical Property of 4-Isopropoxy-3-methoxybenzyl chloride

Chemical Property:

• Boiling Point: 288.2±25.0 °C(Predicted)
• PSA: 18.46000
• Density: 1.081±0.06 g/cm3(Predicted)
• LogP: 3.22120

Purity/Quality:

98.5% ^*data from raw suppliers

4-(Chloromethyl)-1-isopropoxy-2-methoxybenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Isopropoxy-3-methoxybenzyl chloride

There total 3 articles about 4-Isopropoxy-3-methoxybenzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vanillin (2539-22-2) → vanillin (1036588-32-5)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 ℃;

DOI:10.1016/j.ejmech.2009.09.017

Reference yield:

vanillin (121-33-5,8014-42-4) → vanillin (1036588-32-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: potassium borohydride / methanol / 20 °C

3: thionyl chloride / dichloromethane / 0 °C

With thionyl chloride; potassium borohydride; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2014.08.038

Reference yield:

4-isopropyloxy-3-methoxybenzaldehyde (2538-98-9) → vanillin (1036588-32-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium borohydride / methanol / 20 °C

2: thionyl chloride / dichloromethane / 0 °C

With thionyl chloride; potassium borohydride; In methanol; dichloromethane;

DOI:10.1016/j.ejmech.2014.08.038

upstream raw materials:

vanillin

vanillin

4-isopropyloxy-3-methoxybenzaldehyde

Downstream raw materials:

vanillin

lamellarin D

14-(4-hydroxy-3-methoxyphenyl)-3,11-dihydroxy-2,12-dimethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Refernces

• 1、 Shen, Li,Yang, Xiaochun,Yang, Bo,He, Qiaojun,Hu, Yongzhou. "Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents". scheme or table. p. 11 - 18. Retrieved 2010/03/03.