Phosphoric acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine

Base Information

• Chemical Name: Phosphoric acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine
• CAS No.: 134009-27-1
• Molecular Formula: C₆H₁₅N*C₅₀H₅₃ClN₅O₁₀PSi
• Molecular Weight: 1079.7
• Mol file: 134009-27-1.mol

Synonyms:Phosphoric acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine

Chemical Property of Phosphoric acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine

There total 2 articles about Phosphoric acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triethylamine carbonate (15715-58-9) + N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (81256-88-4) + triethylamine (121-44-8) + 2-chlorophenyl dichlorophosphate (15074-54-1) → Phosphoric acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine (134009-27-1)

Guidance literature:

N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide; triethylamine; 2-chlorophenyl dichlorophosphate; With 1,2,4-Triazole; In dichloromethane;

triethylamine carbonate;

DOI:10.1007/s11426-019-9662-5

Reference yield:

N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (81256-88-4) + triethylamine (121-44-8) + 2-chlorophenyl dichlorophosphate (15074-54-1) → Phosphoric acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine (134009-27-1)

Guidance literature:

With pyridine; Yield given. Multistep reaction; 1) H₂O, 2) CH₂Cl₂;

DOI:10.1016/S0040-4020(01)80945-5

Reference yield:

C25H33ClN5O8PSi + Phosphoric acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine (134009-27-1) → C51H61Cl2N9O14P2Si2

Guidance literature:

C₂₅H₃₃ClN₅O₈PSi; Phosphoric acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine; With pyridine; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; In dichloromethane; at 20 ℃;

With dichloro-acetic acid; In dichloromethane; for 0.0833333h; Cooling;

DOI:10.1016/j.bmc.2020.115899

upstream raw materials:

N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

triethylamine

2-chlorophenyl dichlorophosphate

triethylamine carbonate

Downstream raw materials:

N⁶-Benzoyl-3'-O-(tert-butyldimethylsilyl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat