4-Fluoro-2-hydroxybenzonitrile

Base Information

Chemical Name:4-Fluoro-2-hydroxybenzonitrile
CAS No.:186590-01-2
Molecular Formula:C7H4FNO
Molecular Weight:137.113
Hs Code.:2926907090
European Community (EC) Number:866-769-7
DSSTox Substance ID:DTXSID70452436
Nikkaji Number:J833.227D
Mol file:186590-01-2.mol

Synonyms:4-FLUORO-2-HYDROXYBENZONITRILE;186590-01-2;Benzonitrile, 4-fluoro-2-hydroxy-;4-fluoro-2-hydroxy-benzonitrile;2-HYDROXY-4-FLUOROBENZONITRILE;SCHEMBL2525720;2-CYANO-5-FLUOROPHENOL;DTXSID70452436;ZAYFMRICIYQIAP-UHFFFAOYSA-N;CL8212;MFCD13185487;AKOS015856126;DS-9370;MB13366;A4128;CS-0044038;FT-0714098;EN300-136522

Suppliers and Price of 4-Fluoro-2-hydroxybenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Cyano-5-fluorophenol
25g
$ 1130.00

TRC
2-Cyano-5-fluorophenol
2.5g
$ 165.00

SynQuest Laboratories
4-Fluoro-2-hydroxybenzonitrile
5 g
$ 197.00

Chemenu
4-fluoro-2-hydroxybenzonitrile 95+%
25g
$ 542.00

Chemenu
4-fluoro-2-hydroxybenzonitrile 95+%
5g
$ 133.00

Chemenu
4-fluoro-2-hydroxybenzonitrile 95+%
10g
$ 231.00

Ambeed
4-Fluoro-2-hydroxybenzonitrile 98%
1g
$ 14.00

Ambeed
4-Fluoro-2-hydroxybenzonitrile 98%
250mg
$ 14.00

Ambeed
4-Fluoro-2-hydroxybenzonitrile 98%
5g
$ 125.00

Ambeed
4-Fluoro-2-hydroxybenzonitrile 98%
10g
$ 125.00

Total 30 raw suppliers

Chemical Property of 4-Fluoro-2-hydroxybenzonitrile

Chemical Property:

PSA：44.02000
LogP:1.40298
Storage Temp.:Inert atmosphere,Room Temperature
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:137.027691913
Heavy Atom Count:10
Complexity:162

Purity/Quality:

97% ^*data from raw suppliers

2-Cyano-5-fluorophenol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)O)C#N
Uses 2-Cyano-5-fluorophenol is used in the study of substituent effect on fluorobenzene derivatives on cytochrome P 450-catalyzed hydroxylation at adjacent ortho aromatic carbon center.

Technology Process of 4-Fluoro-2-hydroxybenzonitrile

There total 4 articles about 4-Fluoro-2-hydroxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 191014-55-8
2-methoxy-4-fluorobenzonitrile

: 186590-01-2
4-fluoro-2-hydroxybenzonitrile

Guidance literature:: With aluminum (III) chloride; In toluene; at 130 ℃; for 18h;

Reference yield:

: C₈H₆BF₃NOS^(1-)*H⁽¹⁺⁾

: 186590-01-2
4-fluoro-2-hydroxybenzonitrile

Guidance literature:: With water; sodium hydroxide; In 1,2-dichloro-ethane; at 80 ℃; for 0.5h; Inert atmosphere;
DOI:10.1039/d0ob00737d

Reference yield:

: 372-20-3
3-fluorophenol

: 186590-01-2
4-fluoro-2-hydroxybenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum (III) chloride / 1,2-dichloro-ethane / 24 h / 80 °C / Inert atmosphere

2: sodium hydroxide; water / 1,2-dichloro-ethane / 0.5 h / 80 °C / Inert atmosphere

With aluminum (III) chloride; water; sodium hydroxide; In 1,2-dichloro-ethane;
DOI:10.1039/d0ob00737d