2-ethyoxyl-4-broMobenzonitrile

Base Information

• Chemical Name: 2-ethyoxyl-4-broMobenzonitrile
• CAS No.: 1255870-63-3
• Molecular Formula: C9H8BrNO
• Molecular Weight: 226.073
• Mol file: 1255870-63-3.mol

Synonyms:2-ethyoxyl-4-broMobenzonitrile;4-BroMo-2-ethoxybenzonitrile;Ethoxy-4-bromobenzonitrile

Chemical Property of 2-ethyoxyl-4-broMobenzonitrile

Chemical Property:

• PSA: 33.02000
• LogP: 2.71948
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-2-ethoxybenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ethyoxyl-4-broMobenzonitrile

There total 3 articles about 2-ethyoxyl-4-broMobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl iodide (75-03-6) + 4-fluoro-2-hydroxybenzonitrile (186590-01-2) → 4-bromo-2-ethoxybenzonitrile (1255870-63-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield: 88.0%

ethyl iodide (75-03-6) + 4-bromo-2-hydroxy-benzonitrile (288067-35-6) → 4-bromo-2-ethoxybenzonitrile (1255870-63-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

ethanol (64-17-5) + 4-bromo-6-fluorobenzonitrile (105942-08-3) → 4-bromo-2-ethoxybenzonitrile (1255870-63-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

upstream raw materials:

ethanol

4-bromo-6-fluorobenzonitrile

ethyl iodide

4-fluoro-2-hydroxybenzonitrile

Downstream raw materials:

2-ethoxy-4-(5-formylpyridin-3-yl)benzonitrile

N-((5-(4-cyano-3-ethoxyphenyl)pyridin-3-yl)methyl)ethanesulfonamide

Refernces

• 1、 -. "NOVEL THIOUREA DERIVATIVES AS ACTIVATORS OF RORalpha AND PHARMACEUTICAL COMPOSITION CONTAINING SAME". Paragraph 0151. . Retrieved 2018/11/02.