L-LEUCINE-D3-N-FMOC (METHYL-D3)

Base Information

• Chemical Name: L-LEUCINE-D3-N-FMOC (METHYL-D3)
• CAS No.: 538372-74-6
• Molecular Formula: CH3CH(CD3)CH2CH(NH-t-BOC)COOH?H2O
• Molecular Weight: 378.48
• Mol file: 538372-74-6.mol

Synonyms:

Chemical Property of L-LEUCINE-D3-N-FMOC (METHYL-D3)

Chemical Property:

• PSA: 75.63000
• LogP: 4.41530

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-Leu-OH-5,5,5-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fmoc-Leu-OH-5,5,5-d3 is an isotope labelled compound of Fmoc-L-Leu-OH (F625015). Fmoc-L-Leu-OH is an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs.

Technology Process of L-LEUCINE-D3-N-FMOC (METHYL-D3)

There total 2 articles about L-LEUCINE-D3-N-FMOC (METHYL-D3) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-fluorenylmethyl N-succinimidyl carbonate (102774-86-7) + δd3-L-leucine → C21H20(2)H3NO4 (538372-74-6)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water; at 0 - 25 ℃;

DOI:10.1016/j.bmc.2018.01.027

Reference yield:

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + δd3-L-leucine → C21H20(2)H3NO4 (538372-74-6)

Guidance literature:

DOI:10.1016/j.bmcl.2009.02.022

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

9-fluorenylmethyl N-succinimidyl carbonate

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