3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl fluoride

Base Information

• Chemical Name: 3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl fluoride
• CAS No.: 934664-19-4
• Molecular Formula: C13H6F4INO
• Molecular Weight: 395.095
• Hs Code.: 2922499990
• Mol file: 934664-19-4.mol

Synonyms:3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl fluoride;

Chemical Property of 3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl fluoride

Chemical Property:

• PSA: 29.10000
• LogP: 4.63480

Purity/Quality:

99% ^*data from raw suppliers

3,4-Difluoro-2-((2-fluoro-4-iodophenyl)-amino)benzoyl fluoride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl fluoride

There total 1 articles about 3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid (391211-97-5) → 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl fluoride (934664-19-4)

Guidance literature:

With pyridine; trifluoro-[1,3,5]triazine; In dichloromethane; at 0 - 20 ℃; for 2.16667h;

Reference yield: 79.0%

1,1-dimethylethyl [(1S)-1-(3-hydroxyazetidin-3-yl)ethyl]carbamate + 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl fluoride (934664-19-4) → 1,1-dimethylethyl {(1S)-1-[1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-hydroxyazetidin-3-yl]ethyl}carbamate (1373446-70-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/ml300049d

Reference yield: 74.0%

1,1-dimethylethyl (2R)-2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate (934666-39-4,934666-06-5) + 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl fluoride (934664-19-4) → tert-butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate (934665-56-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

upstream raw materials:

3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid

Downstream raw materials:

tert-butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate

1,1-dimethylethyl {(1R)-1-[1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-hydroxyazetidin-3-yl]ethyl}carbamate

1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-(morpholin-4-ylmethyl)azetidin-3-ol trifluoroacetate salt

1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-(1H-imidazol-2-ylmethyl)azetidin-3-ol acetate salt

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