1-Piperidinecarboxylic acid, 2-[1-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]benzoyl]-3-hydroxy-3-azetidinyl]-, 1,1-diMethylethyl ester, (2R)-

Base Information Edit

Chemical Name:1-Piperidinecarboxylic acid, 2-[1-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]benzoyl]-3-hydroxy-3-azetidinyl]-, 1,1-diMethylethyl ester, (2R)-
CAS No.:934665-56-2
Molecular Formula:C₂₆H₂₉F₃IN₃O₄
Molecular Weight:631.434
Hs Code.:
Mol file:934665-56-2.mol

Synonyms:1-Piperidinecarboxylic acid, 2-[1-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]benzoyl]-3-hydroxy-3-azetidinyl]-, 1,1-diMethylethyl ester, (2R)-

Suppliers and Price of 1-Piperidinecarboxylic acid, 2-[1-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]benzoyl]-3-hydroxy-3-azetidinyl]-, 1,1-diMethylethyl ester, (2R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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1-Piperidinecarboxylicacid,2-[1-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl]-3-hydroxy-3-azetidinyl]-,1,1-dimethylethylester,(2R)-
1g
$ 4400.00

Total 4 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 2-[1-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]benzoyl]-3-hydroxy-3-azetidinyl]-, 1,1-diMethylethyl ester, (2R)- Edit

Chemical Property:

Boiling Point:621.1±55.0 °C(Predicted)
PKA:12.70±0.20(Predicted)
PSA：82.11000
Density:1.604±0.06 g/cm3(Predicted)
LogP:5.37740

Purity/Quality:

≥95% ^*data from raw suppliers

1-Piperidinecarboxylicacid,2-[1-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl]-3-hydroxy-3-azetidinyl]-,1,1-dimethylethylester,(2R)- ^*data from reagent suppliers

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Technology Process of 1-Piperidinecarboxylic acid, 2-[1-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]benzoyl]-3-hydroxy-3-azetidinyl]-, 1,1-diMethylethyl ester, (2R)-

There total 37 articles about 1-Piperidinecarboxylic acid, 2-[1-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]benzoyl]-3-hydroxy-3-azetidinyl]-, 1,1-diMethylethyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 934666-39-4,934666-06-5
(R,S) tert-butyl 2-(3-hydroxy-3-azetidinyl)-1-piperidinecarboxylate

: 391211-97-5
3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid

: 934665-56-2
(R,S) tert-butyl 2-{1-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl]-3-hydroxy-3-azetidinyl}-1-piperidinecarboxylate

Guidance literature:: 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

(R,S) tert-butyl 2-(3-hydroxy-3-azetidinyl)-1-piperidinecarboxylate; In acetonitrile; at 20 ℃;