1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-(1H-imidazol-2-ylmethyl)azetidin-3-ol acetate salt

Base Information

Chemical Name:1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-(1H-imidazol-2-ylmethyl)azetidin-3-ol acetate salt
CAS No.:934665-82-4
Molecular Formula:C₂H₄O₂*C₂₀H₁₆F₃IN₄O₂
Molecular Weight:588.325
Hs Code.:

Synonyms:1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-(1H-imidazol-2-ylmethyl)azetidin-3-ol acetate salt

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Chemical Property of 1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-(1H-imidazol-2-ylmethyl)azetidin-3-ol acetate salt

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Technology Process of 1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-(1H-imidazol-2-ylmethyl)azetidin-3-ol acetate salt

There total 2 articles about 1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-(1H-imidazol-2-ylmethyl)azetidin-3-ol acetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 934664-19-4
3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl fluoride

: 1035351-04-2
3-(1H-imidazol-2-ylmethyl)azetidin-3-ol trifluoroacetate salt

: 64-19-7,77671-22-8
acetic acid

: 934665-82-4
1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-(1H-imidazol-2-ylmethyl)azetidin-3-ol acetate salt

Guidance literature:: 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl fluoride; 3-(1H-imidazol-2-ylmethyl)azetidin-3-ol trifluoroacetate salt; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 3h;

acetic acid;

Reference yield: 13.0%

: 934664-19-4
3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl fluoride

: 1035351-04-2
3-(1H-imidazol-2-ylmethyl)azetidin-3-ol trifluoroacetate salt

: 141-78-6
ethyl acetate

: 934665-82-4
1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-(1H-imidazol-2-ylmethyl)azetidin-3-ol acetate salt

Guidance literature:: 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl fluoride; 3-(1H-imidazol-2-ylmethyl)azetidin-3-ol trifluoroacetate salt; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 3h;

ethyl acetate; With sodium hydrogencarbonate; In tetrahydrofuran; water;