2-(2,6-dibroMophenyl)acetonitrile

Base Information

• Chemical Name: 2-(2,6-dibroMophenyl)acetonitrile
• CAS No.: 67197-53-9
• Molecular Formula: C8H5Br2N
• Molecular Weight: 274.942
• Hs Code.: 2926909090
• Mol file: 67197-53-9.mol

Synonyms:Benzeneacetonitrile, 2,6-dibromo-; 2,6-dibromo-benzeneacetonitrile

Chemical Property of 2-(2,6-dibroMophenyl)acetonitrile

Chemical Property:

• Vapor Pressure: 0.000139mmHg at 25°C
• Boiling Point: 333.1°C at 760 mmHg
• Flash Point: 155.3°C
• PSA: 23.79000
• Density: 1.857g/cm³
• LogP: 3.27768
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98.5% ^*data from raw suppliers

2-(2,6-Dibromophenyl)acetonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,6-dibroMophenyl)acetonitrile

There total 8 articles about 2-(2,6-dibroMophenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

potassium cyanide + 1,3-dibromo-2-(chloromethyl)benzene (858006-31-2) → 2-(2,6-dibromophenyl)acetonitrile (67197-53-9)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃; for 48h;

Reference yield: 87.0%

potassium cyanide + 2,6-dibromobenzyl bromide (93701-32-7) → 2-(2,6-dibromophenyl)acetonitrile (67197-53-9)

Guidance literature:

In ethanol; water; for 5h; Reflux;

Reference yield: 81.0%

trimethylsilyl cyanide (7677-24-9) + 2,6-dibromotoluene (69321-60-4) → 2-(2,6-dibromophenyl)acetonitrile (67197-53-9)

Guidance literature:

2,6-dibromotoluene; With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 2h; Heating;

trimethylsilyl cyanide; With tetrabutyl ammonium fluoride; In tetrahydrofuran; acetonitrile; at 20 ℃; for 2h; Further stages.;

DOI:10.1002/adsc.200700099

upstream raw materials:

(2,6-Dibromo-phenyl)-acetaldehyde oxime

2,6-dibromobenzyl bromide

potassium cyanide

trimethylsilyl cyanide

Downstream raw materials:

2-(2,6-dibromophenyl)acetic acid

C₁₂H₁₃Br₂N

6-(2,6-dibromo-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one

N-methyl-2,6-dibromophenylacetamide

Refernces

• 1、 -. "KRAS G12C INHIBITORS". . . Retrieved 2021/06/22.
• 2、 Bennett, Lawrence R.,Blankley, C. John,Fleming, Robert W.,Smith, Ronald D.,Tessman, Deirdre K.. "Antihypertensive Activity of 6-Arylpyridopyrimidin-7-amine Derivatives". . p. 382 - 389. Retrieved 2007/10/02.