4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

Base Information

• Chemical Name: 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine
• CAS No.: 944401-55-2
• Molecular Formula: C11H18BN3O2
• Molecular Weight: 235.094
• Hs Code.: 2934999090
• Mol file: 944401-55-2.mol

Synonyms:4-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-ylamine;4-methyl-5-(4,4,5,5-tetramethyl (1,3,2-dioxaborolan-2-yl))pyrimidine-2-ylamine;4-methyl-5-(4,4,5,5-tetramethyl (1,3,2-dioxaborolan-2-yl)) pyrimidine-2-ylamin;4-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxoborolan-2-yl)-pyrimidin-2-ylamine;QC-141;4-Methyl-2-aminopyrimidine-5-boronic acid pinacol ester;查看更多英文别名收起

Chemical Property of 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

Chemical Property:

• PSA: 70.26000
• Density: 1.11
• LogP: 1.24760
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99%, ^*data from raw suppliers

4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-4-methylpyrimidine-5-boronic acid pinacol ester is used as pharmaceutical intermediate.

Technology Process of 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

There total 1 articles about 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-4-methylpyrimidine-2-ylamine (17321-93-6) + bis(pinacol)diborane (73183-34-3) → 4-Methyl-pyrimidin-2-ylamin (108-52-1) + 4-methyl-5-(4,4,5,5-tetramethyl (1,3,2-dioxaborolan-2-yl))pyrimidine-2-ylamine (944401-55-2)

Guidance literature:

With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 115 ℃; for 18.25h; Heating / reflux;

Reference yield:

4-methyl-5-(4,4,5,5-tetramethyl (1,3,2-dioxaborolan-2-yl))pyrimidine-2-ylamine (944401-55-2) + tert-butyl-6-(4-bromo-6-chloro-1-(4-fluoro-3,5-dimethylbenzyl)-1H-benzo[d]imidazol-2-yl)-2,6-diazaspiro[3.3]heptane-2-carboxylate → C31H35ClFN7O2

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In ethanol; N,N-dimethyl-formamide; at 90 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b01108

Reference yield:

4-methyl-5-(4,4,5,5-tetramethyl (1,3,2-dioxaborolan-2-yl))pyrimidine-2-ylamine (944401-55-2) + tert-butyl-6-(4-bromo-6-chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-2,6-diazaspiro[3.3]heptane-2-carboxylate → C29H31ClFN7O2

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In ethanol; N,N-dimethyl-formamide; at 90 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b01108

upstream raw materials:

5-bromo-4-methylpyrimidine-2-ylamine

bis(pinacol)diborane

Downstream raw materials:

GNE-490

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