p-(p-Methoxybenzamido)benzoic acid 2-(4-hydroxy-3-methoxybenzylidene)h ydrazide

Base Information

• Chemical Name: p-(p-Methoxybenzamido)benzoic acid 2-(4-hydroxy-3-methoxybenzylidene)h ydrazide
• CAS No.: 100278-35-1
• Molecular Formula: C₂₃H₂₁N₃O₅
• Molecular Weight: 419.437
• Mol file: 100278-35-1.mol

Synonyms:Benzoicacid, 4-[(4-methoxybenzoyl)amino]-, [(4-hydroxy-3-methoxyphenyl)methylene]hydrazide(9CI)

Chemical Property of p-(p-Methoxybenzamido)benzoic acid 2-(4-hydroxy-3-methoxybenzylidene)h ydrazide

Chemical Property:

• Vapor Pressure: 3.23E-12mmHg at 25°C
• Boiling Point: 551.7°Cat760mmHg
• Flash Point: 287.4°C
• PSA: 105.76000
• Density: 1.33g/cm³
• LogP: 3.58980

Purity/Quality:

P-(P-METHOXYBENZAMIDO)BENZOIC ACID 2-(4-HYDROXY-3-METHOXYBENZYLIDENE)H YDRAZIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of p-(p-Methoxybenzamido)benzoic acid 2-(4-hydroxy-3-methoxybenzylidene)h ydrazide

There total 4 articles about p-(p-Methoxybenzamido)benzoic acid 2-(4-hydroxy-3-methoxybenzylidene)h ydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

vanillin (121-33-5,8014-42-4) + 4-(4-methoxybenzoylamino)benzoyl hydrazine (100278-53-3) → N-{4-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(Z)-ylidene-hydrazinocarbonyl]-phenyl}-4-methoxy-benzamide (100278-35-1)

Guidance literature:

In ethanol; for 3h; Heating;

Reference yield:

4-methoxy-benzoyl chloride (100-07-2) → N-{4-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(Z)-ylidene-hydrazinocarbonyl]-phenyl}-4-methoxy-benzamide (100278-35-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / dioxane / 1 h / 10 °C

2: 92 percent / N₂H₄ / 2 h / Heating

3: 72 percent / ethanol / 3 h / Heating

With hydrazine; In 1,4-dioxane; ethanol;

Reference yield:

Ethyl-4-(4-methoxybenzoylamino)benzoate (100278-51-1) → N-{4-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(Z)-ylidene-hydrazinocarbonyl]-phenyl}-4-methoxy-benzamide (100278-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / N₂H₄ / 2 h / Heating

2: 72 percent / ethanol / 3 h / Heating

With hydrazine; In ethanol;

upstream raw materials:

vanillin

4-(4-methoxybenzoylamino)benzoyl hydrazine

4-methoxy-benzoyl chloride

Ethyl-4-(4-methoxybenzoylamino)benzoate

Refernces