4-(4-chlorophenoxy)-3,5-difluoroaniline

Base Information

• Chemical Name: 4-(4-chlorophenoxy)-3,5-difluoroaniline
• CAS No.: 549547-33-3
• Molecular Formula: C12H8ClF2NO
• Molecular Weight: 255.651
• Mol file: 549547-33-3.mol

Synonyms:4-(4-Chlorophenoxy)-3,5-difluorobenzenamine;Benzenamine, 4-(4-chlorophenoxy)-3,5-difluoro-;4-(4-chlorophenoxy)-3,5-difluoroaniline ISO 9001：2015 REACH

Chemical Property of 4-(4-chlorophenoxy)-3,5-difluoroaniline

Chemical Property:

• Boiling Point: 309.3±42.0 °C(Predicted)
• PKA: 2.57±0.10(Predicted)
• PSA: 35.25000
• Density: 1.399±0.06 g/cm3(Predicted)
• LogP: 4.57390

Purity/Quality:

98% ^*data from raw suppliers

4-(4-Chlorophenoxy)-3,5-difluorophenylamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-chlorophenoxy)-3,5-difluoroaniline

There total 4 articles about 4-(4-chlorophenoxy)-3,5-difluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-chlorophenoxy)-3,5-difluoronitrobenzene (549547-32-2) + iron (7439-89-6) → 4-(4-chlorophenoxy)-3,5-difluoroaniline (549547-33-3)

Guidance literature:

With ammonium acetate; In water; toluene;

Reference yield:

4-(4-chlorophenoxy)-3,5-difluoronitrobenzene (549547-32-2) → 4-(4-chlorophenoxy)-3,5-difluoroaniline (549547-33-3)

Guidance literature:

With ammonium acetate; iron; for 2 - 3h; Heating / reflux;

Reference yield:

3,4,5-trifluoronitrobenzene (66684-58-0) → 4-(4-chlorophenoxy)-3,5-difluoroaniline (549547-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide

2: ammonium acetate / toluene; water

With ammonium acetate; caesium carbonate; In water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

4-(4-chlorophenoxy)-3,5-difluoronitrobenzene

4-chloro-phenol

3,4,5-trifluoronitrobenzene

iron