2-benzyl-2,5-diazaspiro[3.4]octane

Base Information

• Chemical Name: 2-benzyl-2,5-diazaspiro[3.4]octane
• CAS No.: 1159823-70-7
• Molecular Formula: C₁₃H₁₈N₂*2ClH
• Molecular Weight: 275.221
• Hs Code.: 2933990090
• Mol file: 1159823-70-7.mol

Synonyms:2-benzyl-2,5-diazaspiro[3.4]octane;2,5-Diazaspiro[3.4]octane, 2-(phenylMethyl)-, (Hydrochloride) (1:2)

Chemical Property of 2-benzyl-2,5-diazaspiro[3.4]octane

Chemical Property:

• PSA: 15.27000
• LogP: 3.49510

Purity/Quality:

98%min ^*data from raw suppliers

2-(Phenylmethyl)-2,5-diazaspiro[3.4]octaneDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-benzyl-2,5-diazaspiro[3.4]octane

There total 5 articles about 2-benzyl-2,5-diazaspiro[3.4]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

7-benzyl-1,7-diazaspiro[4.3]octane-1-carboxylic acid tert-butyl ester (1415562-45-6) → 2-benzyl-2,5-diazaspiro[3.4]octane dihydrochloride (1159823-70-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 12h;

Reference yield:

tert-butyl 2-[(benzylamino)methyl]-2-(hydroxymethyl)pyrrolidine-1-carboxylate (1421372-20-4) → 2-benzyl-2,5-diazaspiro[3.4]octane dihydrochloride (1159823-70-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C

1.2: 24 h / 80 °C

2.1: hydrogenchloride / ethyl acetate / 12 h

With hydrogenchloride; carbon tetrabromide; triphenylphosphine; In dichloromethane; ethyl acetate;

Reference yield:

tert-butyl 2-benzyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate (1206970-01-5) → 2-benzyl-2,5-diazaspiro[3.4]octane dihydrochloride (1159823-70-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 12 h / 80 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C

2.2: 24 h / 80 °C

3.1: hydrogenchloride / ethyl acetate / 12 h

With hydrogenchloride; carbon tetrabromide; dimethylsulfide borane complex; triphenylphosphine; In tetrahydrofuran; dichloromethane; ethyl acetate;

upstream raw materials:

7-benzyl-1,7-diazaspiro[4.3]octane-1-carboxylic acid tert-butyl ester

tert-butyl 2-[(benzylamino)methyl]-2-(hydroxymethyl)pyrrolidine-1-carboxylate

tert-butyl 2-benzyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

benzylaminoacetonitrile

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