2-benzyl-2,5-Diazaspiro[3.4]octane-5-carboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:2-benzyl-2,5-Diazaspiro[3.4]octane-5-carboxylic acid 1,1-dimethylethyl ester
CAS No.:1415562-45-6
Molecular Formula:C₁₈H₂₆N₂O₂
Molecular Weight:302.417
Hs Code.:
Mol file:1415562-45-6.mol

Synonyms:2-benzyl-2,5-Diazaspiro[3.4]octane-5-carboxylic acid 1,1-dimethylethyl ester;tert-butyl 2-benzyl-2,5-diazaspiro[3.4]octane-5-carboxylate, 4-methylbenzenesulfonate salt

Suppliers and Price of 2-benzyl-2,5-Diazaspiro[3.4]octane-5-carboxylic acid 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of 2-benzyl-2,5-Diazaspiro[3.4]octane-5-carboxylic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

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Technology Process of 2-benzyl-2,5-Diazaspiro[3.4]octane-5-carboxylic acid 1,1-dimethylethyl ester

There total 10 articles about 2-benzyl-2,5-Diazaspiro[3.4]octane-5-carboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 2-chloromethyl-2-formylpyrrolidine-1-carboxylic acid tert-butyl ester

: 100-46-9
benzylamine

: 1415562-45-6
7-benzyl-1,7-diazaspiro[4.3]octane-1-carboxylic acid tert-butyl ester

Guidance literature:: 2-chloromethyl-2-formylpyrrolidine-1-carboxylic acid tert-butyl ester; benzylamine; In methanol; toluene; at 40 ℃; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 12h;

With triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 16h;

Reference yield: 58.0%

: 1421372-20-4
tert-butyl 2-[(benzylamino)methyl]-2-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1415562-45-6
7-benzyl-1,7-diazaspiro[4.3]octane-1-carboxylic acid tert-butyl ester

Guidance literature:: tert-butyl 2-[(benzylamino)methyl]-2-(hydroxymethyl)pyrrolidine-1-carboxylate; With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 2h;

With triethylamine; In acetonitrile; at 80 ℃; for 24h;

Reference yield:

: 1206970-01-5
tert-butyl 2-benzyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

: 1415562-45-6
7-benzyl-1,7-diazaspiro[4.3]octane-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 12 h / 80 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C

2.2: 24 h / 80 °C

With carbon tetrabromide; dimethylsulfide borane complex; triphenylphosphine; In tetrahydrofuran; dichloromethane;