tert-butyl 2-benzyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Base Information

Chemical Name:tert-butyl 2-benzyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS No.:1206970-01-5
Molecular Formula:C₁₈H₂₄N₂O₃
Molecular Weight:316.4
Hs Code.:
Mol file:1206970-01-5.mol

Synonyms:tert-butyl 2-benzyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Suppliers and Price of tert-butyl 2-benzyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2-Benzyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylic acid tert-butyl ester
250 mg
$ 680.00

BroadPharm
2-Benzyl-1-oxo-2,5-diaza-spiro[3.4]octane-5-carboxylicacidtert-butylester
250 MG
$ 295.00

Apolloscientific
2-Benzyl-1-oxo-2,5-diaza-spiro[3.4]octane-5-carboxylicacidtert-butylester
250mg
$ 617.00

Total 6 raw suppliers

Chemical Property of tert-butyl 2-benzyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Chemical Property:

Purity/Quality:

≥95% ^*data from raw suppliers

2-Benzyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylic acid tert-butyl ester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 2-benzyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

There total 7 articles about tert-butyl 2-benzyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1621421-86-0
tert-butyl 2-(benzylcarbamoyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1206970-01-5
tert-butyl 2-benzyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 4h; Sonication; Inert atmosphere;

Reference yield: 76.0%

: 3010-05-7
benzylaminoacetonitrile

: 145681-01-2
(+/-)-N-tert-butoxycarbonylproline methyl ester

: 1206970-01-5
tert-butyl 2-benzyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: (+/-)-N-tert-butoxycarbonylproline methyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -70 ℃; for 1h; Inert atmosphere;

benzylaminoacetonitrile; In tetrahydrofuran; hexane; at -70 - 20 ℃; for 13h; Inert atmosphere;

Reference yield:

: 15761-39-4,59433-50-0
N-tert-butoxycarbonyl-proline

: 1206970-01-5
tert-butyl 2-benzyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -70 °C / Inert atmosphere

2.2: 13 h / -70 - 20 °C / Inert atmosphere

With n-butyllithium; potassium carbonate; diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;