tert-butyl 2-((benzylamino)methyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 2-((benzylamino)methyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
CAS No.:1421372-20-4
Molecular Formula:
Molecular Weight:320.432
Hs Code.:
Mol file:1421372-20-4.mol

Synonyms:tert-butyl 2-((benzylamino)methyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl 2-((benzylamino)methyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl 2-((benzylamino)methyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

There total 5 articles about tert-butyl 2-((benzylamino)methyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1206970-01-5
tert-butyl 2-benzyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

: 1421372-20-4
tert-butyl 2-[(benzylamino)methyl]-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; at 80 ℃; for 12h;

Reference yield:

: 145681-01-2
(+/-)-N-tert-butoxycarbonylproline methyl ester

: 1421372-20-4
tert-butyl 2-[(benzylamino)methyl]-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -70 °C / Inert atmosphere

1.2: 13 h / -70 - 20 °C / Inert atmosphere

2.1: dimethylsulfide borane complex / tetrahydrofuran / 12 h / 80 °C

With n-butyllithium; dimethylsulfide borane complex; diisopropylamine; In tetrahydrofuran; hexane;

Reference yield:

: 3010-05-7
benzylaminoacetonitrile

: 1421372-20-4
tert-butyl 2-[(benzylamino)methyl]-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -70 °C / Inert atmosphere

1.2: 13 h / -70 - 20 °C / Inert atmosphere

2.1: dimethylsulfide borane complex / tetrahydrofuran / 12 h / 80 °C

With n-butyllithium; dimethylsulfide borane complex; diisopropylamine; In tetrahydrofuran; hexane;