(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride

Base Information

• Chemical Name: (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
• CAS No.: 1402222-66-5
• Molecular Formula: C9H10ClF2N
• Molecular Weight: 205.635
• Mol file: 1402222-66-5.mol

Synonyms:(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine hydrochloride;CyclopropanaMine, 2-(3,4-difluorophenyl)-, hydrochloride (1:1), (1R,2S)-

Chemical Property of (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride

Chemical Property:

• PSA: 26.02000
• LogP: 3.28170
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride

There total 16 articles about (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C11H11F2NO2 → trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine hydrochloride (1402222-66-5,1156491-10-9)

Guidance literature:

With hydrogenchloride; acetic acid; at 100 - 110 ℃; for 10h; Temperature;

Reference yield: 87.0%

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine (1006614-49-8,220352-38-5,1459719-81-3) → trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine hydrochloride (1402222-66-5,1156491-10-9)

Guidance literature:

With hydrogenchloride; In water; at 0 ℃;

Reference yield: 76.0%

tert-butyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate (1350749-64-2) → trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine hydrochloride (1402222-66-5,1156491-10-9)

Guidance literature:

With hydrogenchloride; water; In methanol; at 25 ℃; for 2h;

upstream raw materials:

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbohydrazide

tert-butyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate

trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

Downstream raw materials:

ticagrelor

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine

methyl (((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d](1,3)dioxol-4-yl)oxy)acetate