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1350749-64-2

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1350749-64-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1350749-64-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,0,7,4 and 9 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1350749-64:
(9*1)+(8*3)+(7*5)+(6*0)+(5*7)+(4*4)+(3*9)+(2*6)+(1*4)=162
162 % 10 = 2
So 1350749-64-2 is a valid CAS Registry Number.

1350749-64-2Downstream Products

1350749-64-2Relevant articles and documents

Discovery of new tranylcypromine derivatives as highly potent LSD1 inhibitors

Huang, Ming-Jie,Guo, Jia-Wen,Fu, Yun-Dong,You, Ya-Zhen,Xu, Wen-Yu,Song, Ting-Yu,Li, Ran,Chen, Zi-Tong,Huang, Li-Hua,Liu, Hong-Min

, (2021)

Tranylcypromine (TCP)-based structural modifications lead to the discovery of new LSD1 inhibitors, of which compounds 26b and 29b effectively inhibit LSD1 with the IC50 values of 17 and 11 nM, respectively and also show good selectivity over MAO-B. Mechanistic studies showed that compound 29b concentration-dependently induced H3K4me1/2 accumulation in LSD1 overexpressed MGC-803 cells and also inhibited metastasis of MGC-803 cells. Collectively, both compounds could be promising lead compounds for further investigation.

A method for preparing for standard auspicious Luo river

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Paragraph 0115-0116, (2017/08/25)

The invention provides a ticagrelor preparation method. The method using a compound of structural formula 2 as an initiator comprises the following steps: 1, reacting the compound of structural formula 2 with di-tert-butyl pyrocarbonate to obtain a compound of structural formula 3; 2, reacting the compound of structural formula 3 with a compound of structural formula 4 to obtain a compound of structural formula 5; 3, reacting the compound of structural formula 5 with a compound of structural formula 6 to obtain a compound of structural formula 7; and 4, carrying out nitro group reduction on the compound of structural formula 7, cyclizing, and carrying out protective group removal to obtain ticagrelor of structural formula 1.

SYNTHESIS OF 2-(3,4-DIFLUOROPHENYL)CYCLOPROPANAMINE DERIVATIVES AND SALTS

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Page/Page column 21, (2013/10/21)

The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

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