(S)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

Base Information

• Chemical Name: (S)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate
• CAS No.: 1008562-93-3
• Molecular Formula: C13H24N2O4
• Molecular Weight: 272.345
• Mol file: 1008562-93-3.mol

Synonyms:(S)-3-(indolyl)glycine;(S)-3-(methoxy-methyl-carbamoyl)-piperidine-1-carboxylic acid tert-butyl ester;(S)-Amino-(1H-Indol-3-Yl)acetic acid;(S)-2-AMINO-2-(1H-INDOL-3-YL)ACETIC ACID;(S)-tert-butyl 3-[(methoxymethyl)carbamoyl]piperidine-1-carboxylate;L-tryptophane;L-tryptophan;

Chemical Property of (S)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 343.8±52.0 °C(Predicted)
• PKA: -2.50±0.40(Predicted)
• PSA: 59.08000
• Density: 1.106±0.06 g/cm3(Predicted)
• LogP: 1.59120

Purity/Quality:

97% ^*data from raw suppliers

(S)-tert-Butyl3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

There total 3 articles about (S)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + (3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (88495-54-9) → (S)-3-(methoxy-methyl-carbamoyl)-piperidine-1-carboxylic acid tert-butyl ester (1008562-93-3)

Guidance literature:

With N-methylcyclohexylamine; chloroformic acid ethyl ester; In dichloromethane; at -78 - 20 ℃; for 4.25h;

Reference yield:

(3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (88495-54-9) + N,0-dimethylhydroxylamine (1117-97-1) → (S)-3-(methoxy-methyl-carbamoyl)-piperidine-1-carboxylic acid tert-butyl ester (1008562-93-3)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

Ν,Ο-dimethylhydroxylamine hydrochloride + (3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (88495-54-9) → (S)-3-(methoxy-methyl-carbamoyl)-piperidine-1-carboxylic acid tert-butyl ester (1008562-93-3)

Guidance literature:

(3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid; With triethylamine; In dichloromethane; for 0.25h;

Ν,Ο-dimethylhydroxylamine hydrochloride; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at -1 - 20 ℃; for 18.25h;

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

(3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid

N,0-dimethylhydroxylamine

Downstream raw materials:

(S)-3-acetyl-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 3-acetylpiperidine-1-carboxylate

3-(1-amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl (3S)-3-(1-hydroxyethyl)piperidine-1-carboxylate