(2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methanol

Base Information

• Chemical Name: (2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methanol
• CAS No.: 1000413-85-3
• Molecular Formula: C19H24O4S
• Molecular Weight: 348.463
• Mol file: 1000413-85-3.mol

Synonyms:2,6-dimethyl-3-nitrobenzyl alcohol;{2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methanol;(2,6-dimethyl-3-nitro-phenyl)-methanol;Benzenemethanol,2,6-dimethyl-3-nitro;[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]-[1,1'-biphenyl]-3-yl]methanol;2,6-dimethyl-3-nitrobenzene-1-methanol;

Chemical Property of (2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methanol

Chemical Property:

• Boiling Point: 559.9±50.0 °C(Predicted)
• PKA: 14.32±0.10(Predicted)
• PSA: 71.98000
• Density: 1.178±0.06 g/cm3(Predicted)
• LogP: 4.35700

Purity/Quality:

99.99%HPLC ^*data from raw suppliers

(2'',6''-Dimethyl-4''-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methanol

There total 7 articles about (2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-carbaldehyde (1000413-84-2) → (2’,6’-dimethyl-4’-(3-(methylsulfonyl)propoxy)-[1,1‘-biphenyl]-3-yl)methanol (1000413-85-3)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 4h;

Reference yield:

2-bromo-5-(3-methanesulfonyl-propoxy)-1,3-dimethyl-benzene (1372195-69-1) + [3-(hydroxymethyl)phenyl]boronic acid (87199-15-3) → (2’,6’-dimethyl-4’-(3-(methylsulfonyl)propoxy)-[1,1‘-biphenyl]-3-yl)methanol (1000413-85-3)

Guidance literature:

With potassium phosphate; tetrabutylammomium bromide; palladium diacetate; triphenylphosphine; In tetrahydrofuran; for 8h; Reflux; Inert atmosphere;

Reference yield:

(3‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenyl)methanol (443776-76-9) + 2-bromo-5-(3-methanesulfonyl-propoxy)-1,3-dimethyl-benzene (1372195-69-1) → (2’,6’-dimethyl-4’-(3-(methylsulfonyl)propoxy)-[1,1‘-biphenyl]-3-yl)methanol (1000413-85-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In tetrahydrofuran; water; for 16h; Inert atmosphere; Reflux;

upstream raw materials:

2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-carbaldehyde

2-bromo-5-(3-methanesulfonyl-propoxy)-1,3-dimethyl-benzene

[3-(hydroxymethyl)phenyl]boronic acid

3-Formylphenylboronic acid

Downstream raw materials:

[(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

[(3R)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

3'-(chloromethyl)-2,6-dimethyl-4-(3-(methylsulfonyl)propoxy)-1,1'-biphenyl

[6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-1-benzofuran-3-yl]acetic acid

Refernces

• 1、 -. "CARBOXYLIC ACID COMPOUNDS IN TREATMENT OF DIABETES MELLITUS". Page/Page column 31. . Retrieved 2015/03/13.
• 2、 Li, Zheng,Wang, Xuekun,Xu, Xue,Yang, Jianyong,Xia, Wenting,Zhou, Xianhao,Huang, Wenlong,Qian, Hai. "Design, synthesis and biological activity of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists". supporting information. p. 7158 - 7164. Retrieved 2015/11/16.