(R)-5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-aMine (Hydrochloride)

Base Information

• Chemical Name: (R)-5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-aMine (Hydrochloride)
• CAS No.: 58349-15-8
• Molecular Formula: C11H15NO.ClH
• Molecular Weight: 213.70384
• Hs Code.: 2922290090
• Mol file: 58349-15-8.mol

Synonyms:(R)-(+)-5-methoxy-2-aminotetraline hydrochloride;"Aminotetraline hydrochloride, (R)-(+)-5-Methoxy-2-";(R)-2-Amino-5-methoxy-1,2,3,4-tetrahydronaphthalene hydrochloride;(R)-5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-aMine (Hydrochloride)

Chemical Property of (R)-5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-aMine (Hydrochloride)

Chemical Property:

• PSA: 35.25000
• LogP: 3.01350

Purity/Quality:

NLT 98% ^*data from raw suppliers

(R)-5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-aMine (Hydrochloride)

There total 9 articles about (R)-5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-aMine (Hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzyl 5-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (1309876-80-9) → SKF 87967 hydrochloride (3880-88-4,58349-15-8,58349-17-0)

Guidance literature:

With chloroform; palladium on carbon; hydrogen; In methanol; at 20 ℃; for 24h;

DOI:10.1080/00397911.2010.495043

Reference yield:

5-methoxy-2-tetralone (32940-15-1) → SKF 87967 hydrochloride (3880-88-4,58349-15-8,58349-17-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 g / 1 N NaOH / ethanol; H₂O / pH 8.2

2: 1.) B₂H₆, 2.) concd. HCl / 1.) THF, reflux, 3 h, 2.) reflux, 15 min

With hydrogenchloride; sodium hydroxide; diborane; In ethanol; water;

DOI:10.1021/jm00344a009

Reference yield:

5-Methoxy-3,4-dihydro-1H-naphthalen-2-one O-methyl-oxime (80270-84-4) → SKF 87967 hydrochloride (3880-88-4,58349-15-8,58349-17-0)

Guidance literature:

With hydrogenchloride; diborane; Yield given. Multistep reaction; 1.) THF, reflux, 3 h, 2.) reflux, 15 min;

DOI:10.1021/jm00344a009

upstream raw materials:

5-Methoxy-3,4-dihydro-1H-naphthalen-2-one O-methyl-oxime

5-methoxy-2-tetralone

benzyl 5-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate

5-bromo-2-naphthalenecarboxylic acid methyl ester

Downstream raw materials:

(R)-5-hydroxy-2-(di-n-propylamino)tetralin

(2S)-5-hydroxy-2-(di-n-propylamino)tetralin

(S)-(-)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride

rotigotine hydrochloride

Refernces

• 1、 DeMarinis, R. M.,Shah, D. H.,Hall, R. F.,Hieble, J. P.,Pendleton, R. G.. "α-Adrenergic Agents. 2. Synthesis and α1-Agonist Activity of 2-Aminotetralins". . p. 136 - 141. Retrieved 2007/10/02.