BI-99179

Base Information

Chemical Name:BI-99179
CAS No.:1291779-76-4
Molecular Formula:C23H25N3O3
Molecular Weight:391.47
Hs Code.:

Synonyms:Cyclopentanecarboxamide, N-[4-(2-benzoxazolyl)phenyl]-N-methyl-3-[(1-oxopropyl)amino]-, (1R,3S)-;(1R,3S)-3-Propionylaminocyclopentanecarboxylic acid N-[4-(benzoxazol-2-yl)phenyl]-N-methylamide;(1R,3S)-N-[4-(2-Benzoxazolyl)phenyl]-N-methyl-3-[(1-oxopropyl)amino]cyclopentanecarboxamide;

Suppliers and Price of BI-99179

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
BI99179 99.78%
10mg
$ 320.00

ChemScene
BI99179 99.78%
5mg
$ 200.00

ChemScene
BI99179 99.78%
100mg
$ 1500.00

ChemScene
BI99179 99.78%
50mg
$ 950.00

Axon Medchem
BI99179 99%
25 mg
$ 594.00

Total 2 raw suppliers

Chemical Property of BI-99179

Chemical Property:

PSA：75.44000
LogP:4.54340

Purity/Quality:

99% ^*data from raw suppliers

BI99179 99.78% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of BI-99179

There total 8 articles about BI-99179 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1291779-73-1
(1R,3S)-3-amino-cyclopentanecarboxylic acid N-(4-benzooxazol-2-yl-phenyl)-N-methyl-amide trifluoro acetic acid

: 79-03-8
propionyl chloride

: 1291779-76-4
(1R,3S)-3-propionylamino-cyclopentanecarboxylic acid N-(4-benzooxazol-2-yl-phenyl)-N-methyl-amide

Guidance literature:: (1R,3S)-3-amino-cyclopentanecarboxylic acid N-(4-benzooxazol-2-yl-phenyl)-N-methyl-amide trifluoro acetic acid; With sodium carbonate;

propionyl chloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2011.07.083

Reference yield:

: 1291779-68-4
(1R,3S)-3-propionylamino-cyclopentanecarboxylic acid

: 2-(p-methylaminophenyl)benzoxazole

: 1291779-76-4
(1R,3S)-3-propionylamino-cyclopentanecarboxylic acid N-(4-benzooxazol-2-yl-phenyl)-N-methyl-amide

Guidance literature:: (1R,3S)-3-propionylamino-cyclopentanecarboxylic acid; In dichloromethane; at 20 ℃;

2-(p-methylaminophenyl)benzoxazole; With 2,4,6-trimethyl-pyridine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2011.07.083

Reference yield:

: 95-55-6
2-amino-phenol

: 1291779-76-4
(1R,3S)-3-propionylamino-cyclopentanecarboxylic acid N-(4-benzooxazol-2-yl-phenyl)-N-methyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: polyphosphoric acid / 4 h / 205 °C

2.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 2 h

2.2: 20 °C

3.1: diethylamine / tetrahydrofuran / 20 - 40 °C

4.1: acetonitrile; water

5.1: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; diethylamine; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;