Technology Process of Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-1,4'-dicarboxylic acid, tetrahydro-6'-oxo-, 1-(1,1-dimethylethyl) 4'-methyl ester, (2R,4'R,8'aR)-
There total 11 articles about Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-1,4'-dicarboxylic acid, tetrahydro-6'-oxo-, 1-(1,1-dimethylethyl) 4'-methyl ester, (2R,4'R,8'aR)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2RS,4R)-2-<<2'-(R)-N-(tert-butoxycarbonyl)-2'-(methoxycarbonyl)pyrrolidinyl>methyl>thiazinane-4-carboxylic acid;
With
triethylamine;
In
N,N-dimethyl-formamide;
at 70 ℃;
for 72h;
methyl iodide;
With
potassium hydrogencarbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 24h;
Further stages.;
DOI:10.1021/jm070723u
- Guidance literature:
-
Multi-step reaction with 6 steps
1: Me4NOH*5H2O / acetonitrile / 48 h / Ambient temperature
2: diethyl ether
3: 1.) OsO4, H2O, 2.) aq. NaIO4 / 1.) THF, RT, 5 min, 2.) THF, RT, overnight
4: 75 percent / aq. NaOH / aq. ethanol / Ambient temperature
5: Et3N / dimethylformamide / 72 h / 70 °C
6: diethyl ether; methanol / 0 °C
With
sodium hydroxide; sodium periodate; osmium(VIII) oxide; tetramethyl ammoniumhydroxide; water; triethylamine;
In
methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm980525q
- Guidance literature:
-
Multi-step reaction with 7 steps
1: H2O, SiO2 / methanol / 48 h / Ambient temperature
2: Me4NOH*5H2O / acetonitrile / 48 h / Ambient temperature
3: diethyl ether
4: 1.) OsO4, H2O, 2.) aq. NaIO4 / 1.) THF, RT, 5 min, 2.) THF, RT, overnight
5: 75 percent / aq. NaOH / aq. ethanol / Ambient temperature
6: Et3N / dimethylformamide / 72 h / 70 °C
7: diethyl ether; methanol / 0 °C
With
sodium hydroxide; sodium periodate; osmium(VIII) oxide; tetramethyl ammoniumhydroxide; water; silica gel; triethylamine;
In
methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm980525q
