(N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-aMinophenylethylaMine

Base Information

• Chemical Name: (N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-aMinophenylethylaMine
• CAS No.: 223673-36-7
• Molecular Formula: C21H28N2O3
• Molecular Weight: 356.465
• Hs Code.: 2924299090
• Mol file: 223673-36-7.mol

Synonyms:(N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-aMinophenylethylaMine;[2-(4-AMinophenyl)ethyl][(2R)-2-hydroxy-2-phenylethyl]carbaMic Acid 1,1-DiMethylethyl Ester

Chemical Property of (N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-aMinophenylethylaMine

Chemical Property:

• PSA: 75.79000
• Density: 1.150
• LogP: 4.36320
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Chloroform

Purity/Quality:

98%,99%, ^*data from raw suppliers

(N-tert-Butoxycarbonyl-N-[(1’R)-hydroxy-1-phenyl)ethyl])-4-aminophenylethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-aMinophenylethylaMine

There total 10 articles about (N-tert-Butoxycarbonyl-N-[(1'R)-hydroxy-1-phenyl)ethyl])-4-aMinophenylethylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

((2R)-2-hydroxy-2-phenylethyl)-[2-(4-nitrophenyl)ethyl]carbamic acid tert-butyl ester (223673-35-6) → (R)-(4-aminophenylethyl)(2-hydroxy-2-phenylethyl)carbamic acid tert-butyl ester (223673-36-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 2h;

DOI:10.1248/cpb.58.533

Reference yield: 88.0%

→ (R)-(4-aminophenylethyl)(2-hydroxy-2-phenylethyl)carbamic acid tert-butyl ester (223673-36-7)

Guidance literature:

Reference yield:

(2R)-2-hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylethanamide (521284-19-5) → (R)-(4-aminophenylethyl)(2-hydroxy-2-phenylethyl)carbamic acid tert-butyl ester (223673-36-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / 70 °C / Cooling with ice

2: triethylamine / tetrahydrofuran / 1 h / 20 °C

3: ammonium chloride; iron / tetrahydrofuran; ethanol; water / 4 h / 75 °C

With sodium tetrahydroborate; boron trifluoride diethyl etherate; iron; ammonium chloride; triethylamine; In tetrahydrofuran; ethanol; water;

upstream raw materials:

di-tert-butyl dicarbonate

YM-208876

p-Aminophenethylamine

(R)-Styrene oxide

Downstream raw materials:

tert-butyl (R)-N-(2-{4-[(2-bromoacetyl)amino]phenyl}ethyl)-N-(2-hydroxy-2-phenylethyl)carbamate

Refernces

• 1、 -. "Aryl or heteroaryl substituted pyrrolidine amide derivatives and application thereof". Paragraph 0230-0232. . Retrieved 2019/05/22.
• 2、 -. "Acyl-substituted pyrrolidine amide derivative and application thereof". Paragraph 0234; 0246; 0247. . Retrieved 2019/06/12.