Chemical Property of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine
Chemical Property:
- Melting Point:220.0-221.4 °C (decomp)
- Boiling Point:669.2±65.0 °C(Predicted)
- PKA:13.11±0.60(Predicted)
- PSA：119.31000
- Density:1.72±0.1 g/cm3(Predicted)
- LogP:-0.22710
- XLogP3:-0.6
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:3
- Exact Mass:293.09241742
- Heavy Atom Count:21
- Complexity:459
- Purity/Quality:
-
97% *data from raw suppliers
Islatravir 99.94% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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Useful:
- Canonical SMILES:C#CC1(C(CC(O1)N2C=NC3=C(N=C(N=C32)F)N)O)CO
- Isomeric SMILES:C#C[C@]1([C@H](C[C@@H](O1)N2C=NC3=C(N=C(N=C32)F)N)O)CO
- Recent ClinicalTrials:Dose Ranging, Switch Study of Islatravir (ISL) and Ulonivirine (MK-8507) Once-Weekly in Virologically-Suppressed Adults With Human Immunodeficiency Virus Type 1 (HIV-1) [MK-8591-013]
- Recent EU Clinical Trials:A Phase 3, Randomized, Active-Controlled, Double-Blind Clinical Study to Evaluate the Efficacy and Safety of Oral Islatravir Once-Monthly as Preexposure Prophylaxis in Cisgender Men and Transgender Women Who Have Sex With Men, and Are at High Risk for HIV-1 Infection
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Uses
4'-ethynyl-2-fluoro-2'-deoxyadenosine is a heterocyclic organic compound and can be used as pharmaceutical intermediates. MK-?8591 is a carbocyclic nucleoside reverse transcriptase translocation inhibitor and is used as an antiviral with potential use towards the treatment of HIV.
