(S)-5-benzyl-2-phenyl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c]

Base Information

• Chemical Name: (S)-5-benzyl-2-phenyl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c]
• CAS No.: 464174-87-6
• Molecular Formula: C18H18N3O.BF4
• Molecular Weight: 379.165
• Mol file: 464174-87-6.mol

Synonyms:(S)-5-benzyl-2-phenyl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c];

Chemical Property of (S)-5-benzyl-2-phenyl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c]

Chemical Property:

• PSA: 30.93000
• LogP: 3.77380

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-5-Benzyl-2-phenyl-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-iumtetrafluoroborate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-5-benzyl-2-phenyl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c]

There total 4 articles about (S)-5-benzyl-2-phenyl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

(S)-5-benzylmorpholin-3-one (101250-48-0) + orthoformic acid triethyl ester (122-51-0) + phenylhydrazine (100-63-0) → (S)-5-benzyl-2-phenyl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (464174-87-6)

Guidance literature:

(S)-5-benzylmorpholin-3-one; With trimethoxonium tetrafluoroborate; In dichloromethane; for 16h;

phenylhydrazine; In dichloromethane; for 20h;

orthoformic acid triethyl ester; In methanol; for 16h; Reflux;

DOI:10.1039/c1ob05160a

Reference yield:

L-Phenylalaninol (3182-95-4) → (S)-5-benzyl-2-phenyl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (464174-87-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 - 20 °C

3.1: trimethoxonium tetrafluoroborate / dichloromethane / 16 h

3.2: 20 h

3.3: 16 h / Reflux

With potassium tert-butylate; trimethoxonium tetrafluoroborate; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c1ob05160a

Reference yield:

(S)-2-chloro-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide (94193-78-9) → (S)-5-benzyl-2-phenyl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (464174-87-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 - 20 °C

2.1: trimethoxonium tetrafluoroborate / dichloromethane / 16 h

2.2: 20 h

2.3: 16 h / Reflux

With potassium tert-butylate; trimethoxonium tetrafluoroborate; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c1ob05160a

upstream raw materials:

L-phenylalanine

L-Phenylalaninol

(S)-2-chloro-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide

(S)-5-benzylmorpholin-3-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 464174-87-6 (S)-5-benzyl-2-phenyl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c]

Send

Send

Metric Ton KG G Pound L ML

Send

Send