CX6258

Base Information

Chemical Name:CX6258
CAS No.:1202916-90-2
Molecular Formula:C26H24ClN3O3
Molecular Weight:461.948
Hs Code.:
Mol file:1202916-90-2.mol

Synonyms:(E)-5-butyl-2-methyl-hexa-2,5-dien-1-ol;(E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one;2-Nonen-1-ol,2-methyl-5-methylene-,(E);

Suppliers and Price of CX6258

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
CX-6258
50mg
$ 330.00

TRC
CX-6258
100mg
$ 495.00

DC Chemicals
CX6258 >98%
1 g
$ 2100.00

DC Chemicals
CX6258 >98%
100 mg
$ 600.00

Crysdot
CX-6258 98+%
50mg
$ 440.00

ChemScene
CX-6258 99.73%
10mg
$ 192.00

ChemScene
CX-6258 99.73%
5mg
$ 144.00

ChemScene
CX-6258 99.73%
50mg
$ 540.00

Chemenu
(E)-5-Chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one 95%+
50mg
$ 505.00

Cayman Chemical
CX-6258 ≥98%
25mg
$ 293.00

Total 27 raw suppliers

Chemical Property of CX6258

Chemical Property:

Boiling Point:697.8±55.0 °C(Predicted)
PKA:11.38±0.20(Predicted)
PSA：69.28000
Density:1.309±0.06 g/cm3(Predicted)
LogP:4.83130
Solubility.:insoluble in EtOH; ≥11.15 mg/mL in DMSO; ≥2.575 mg/mL in H2O with gentle warming

Purity/Quality:

99%, ^*data from raw suppliers

CX-6258 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses CX-6258 is a potent, selective, and orally efficacious pan-Pim kinases inhibitor.

Technology Process of CX6258

There total 9 articles about CX6258 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 17630-75-0
5-chloro-indolin-2-one

: 5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-carbaldehyde

: 1202916-90-2
(E)-(5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one)

Guidance literature:: With piperidine; In ethanol; for 5h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmcl.2015.07.061

Reference yield:

: 4318-37-0
1-Methylhomopiperazine

: 1202918-24-8
(E)-3-(5-((5-chloro-2-oxoindolin-3-ylidene)methyl)furan-2-yl)benzoic acid

: 1202916-90-2
(E)-(5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one)

Guidance literature:: (E)-3-(5-((5-chloro-2-oxoindolin-3-ylidene)methyl)furan-2-yl)benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

1-Methylhomopiperazine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;