CX6258(HCL)

Base Information

Chemical Name:CX6258(HCL)
CAS No.:1353859-00-3
Molecular Formula:C₂₆H₂₄ClN₃O₃*ClH
Molecular Weight:498.409
Hs Code.:
Mol file:1353859-00-3.mol

Synonyms:CX6258(HCL);(3E)-5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-Indol-2-one, hydrochloride (1:1);CX6258(HCL) 2H-Indol-2-one, 5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-, hydro;CX-6258 Hydrochloride

Suppliers and Price of CX6258(HCL)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
CX-6258
25mg
$ 595.00

TRC
CX-6258
5mg
$ 150.00

CSNpharm
CX-6258HCl
5mg
$ 74.00

CSNpharm
CX-6258HCl
25mg
$ 294.00

Axon Medchem
CX6258hydrochloride 99%
25 mg
$ 352.00

Arctom
CX-6258Hydrochloride
5mg
$ 58.00

Ambeed
CX-6258Hydrochloride 98+%
5mg
$ 59.00

AK Scientific
(E)-5-Chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-onehydrochloride
25mg
$ 304.00

AK Scientific
(E)-5-Chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-onehydrochloride
1mg
$ 104.00

Total 9 raw suppliers

Chemical Property of CX6258(HCL)

Chemical Property:

PSA：65.79000
LogP:5.68620
Storage Temp.:Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

CX-6258 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor.

Technology Process of CX6258(HCL)

There total 5 articles about CX6258(HCL) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202916-90-2
(E)-(5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one)

: 1353859-00-3
CX-6258 hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h; Cooling with ice;
DOI:10.1021/ml200259q

Reference yield:

: 304884-54-6
5-(3-carboxyphenyl)furane-2-carbaldehyde

: 1353859-00-3
CX-6258 hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / ethanol / 20 - 40 °C / Inert atmosphere

1.2: 2 h / 0 °C

2.1: hydrogenchloride / water / 0.5 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

3.2: 24 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C / Cooling with ice

With piperidine; hydrogenchloride; 1,1'-carbonyldiimidazole; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ml200259q

Reference yield:

: C₂₀H₁₁ClNO₄^(1-)*Na⁽¹⁺⁾

: 1353859-00-3
CX-6258 hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 0.5 h / 20 °C

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C / Cooling with ice

With hydrogenchloride; 1,1'-carbonyldiimidazole; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ml200259q