(E)-3-(5-((5-chloro-2-oxoindolin-3-ylidene)methyl)furan-2-yl)benzoic acid

Base Information

Chemical Name:(E)-3-(5-((5-chloro-2-oxoindolin-3-ylidene)methyl)furan-2-yl)benzoic acid
CAS No.:1202918-24-8
Molecular Formula:C₂₀H₁₂ClNO₄
Molecular Weight:365.773
Hs Code.:

Synonyms:(E)-3-(5-((5-chloro-2-oxoindolin-3-ylidene)methyl)furan-2-yl)benzoic acid

Suppliers and Price of (E)-3-(5-((5-chloro-2-oxoindolin-3-ylidene)methyl)furan-2-yl)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (E)-3-(5-((5-chloro-2-oxoindolin-3-ylidene)methyl)furan-2-yl)benzoic acid

Chemical Property:

Purity/Quality:: 98%+ ^*data from raw suppliers

Safty Information:

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Technology Process of (E)-3-(5-((5-chloro-2-oxoindolin-3-ylidene)methyl)furan-2-yl)benzoic acid

There total 6 articles about (E)-3-(5-((5-chloro-2-oxoindolin-3-ylidene)methyl)furan-2-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.5%

: C₂₀H₁₁ClNO₄^(1-)*Na⁽¹⁺⁾

: 1202918-24-8
(E)-3-(5-((5-chloro-2-oxoindolin-3-ylidene)methyl)furan-2-yl)benzoic acid

Guidance literature:: With hydrogenchloride; In water; at 20 ℃; for 0.5h;
DOI:10.1021/ml200259q

Reference yield: 70.0%

: 304884-54-6
5-(3-carboxyphenyl)furane-2-carbaldehyde

: 17630-75-0
5-chloro-indolin-2-one

: 1202918-24-8
(E)-3-(5-((5-chloro-2-oxoindolin-3-ylidene)methyl)furan-2-yl)benzoic acid

Guidance literature:: With piperidine; In ethanol; at 35 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmcl.2015.07.061

Reference yield:

: 304884-54-6
5-(3-carboxyphenyl)furane-2-carbaldehyde

: 1202918-24-8
(E)-3-(5-((5-chloro-2-oxoindolin-3-ylidene)methyl)furan-2-yl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: piperidine / ethanol / 20 - 40 °C / Inert atmosphere

1.2: 2 h / 0 °C

2.1: hydrogenchloride / water / 0.5 h / 20 °C

With piperidine; hydrogenchloride; In ethanol; water;
DOI:10.1021/ml200259q