Ethyl 4,6-dichloro-5-fluoropyridine-3-carboxylate, 2,4-Dichloro-5-(ethoxycarbonyl)-3-fluoropyridine

Base Information

• Chemical Name: Ethyl 4,6-dichloro-5-fluoropyridine-3-carboxylate, 2,4-Dichloro-5-(ethoxycarbonyl)-3-fluoropyridine
• CAS No.: 154012-17-6
• Molecular Formula: C8H6Cl2FNO2
• Molecular Weight: 238.046
• Hs Code.: 2933399990
• Mol file: 154012-17-6.mol

Synonyms:Ethyl 4,6-dichloro-5-fluoronicotinate;Ethyl 4,6-dichloro-5-fluoropyridine-3-carboxylate, 2,4-Dichloro-5-(ethoxycarbonyl)-3-fluoropyridine;ethyl 4,6-dichloro-5-fluoropyridine-3-carboxylate

Chemical Property of Ethyl 4,6-dichloro-5-fluoropyridine-3-carboxylate, 2,4-Dichloro-5-(ethoxycarbonyl)-3-fluoropyridine

Chemical Property:

• Boiling Point: 279.1±40.0 °C(Predicted)
• PKA: -2.50±0.10(Predicted)
• PSA: 39.19000
• Density: 1.441±0.06 g/cm3(Predicted)
• LogP: 2.70420
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 4,6-dichloro-5-fluoronicotinate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4,6-dichloro-5-fluoropyridine-3-carboxylate, 2,4-Dichloro-5-(ethoxycarbonyl)-3-fluoropyridine

There total 5 articles about Ethyl 4,6-dichloro-5-fluoropyridine-3-carboxylate, 2,4-Dichloro-5-(ethoxycarbonyl)-3-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethanol (64-17-5) + 2,4-dichloro-3-fluoropyridine-5-carboxylic acid (154012-18-7) → ethyl 2,4-dichloro-3-fluoropyridine-5-carboxylate (154012-17-6)

Guidance literature:

With thionyl chloride; at 65 - 80 ℃;

Reference yield: 27.0%

2,4-dichloro-5-(ethoxycarbonyl)-3-pyridinediazonium hexafluorophosphate → ethyl 2,4-dichloro-3-fluoropyridine-5-carboxylate (154012-17-6)

Guidance literature:

at 150 ℃;

DOI:10.1002/jhet.5570300402

Reference yield:

ethyl 2,4-dihydroxy-3-nitropyridine-5-carboxylate (6317-97-1) → ethyl 2,4-dichloro-3-fluoropyridine-5-carboxylate (154012-17-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 73 percent / POCl₃ / 48 h / 115 °C

2: 94 percent / H₂ / Raney-nickel / tetrahydrofuran / 21 h / 26 - 34 °C / 1241.2 - 2585.7 Torr

3: 91 percent / hexafluorophosphoric acid, aq. NaNO₂ / 0.08 h

4: 27 percent / 150 °C

With hexafluorophosphoric acid; hydrogen; sodium nitrite; trichlorophosphate; nickel; In tetrahydrofuran;

DOI:10.1002/jhet.5570300402

upstream raw materials:

ethyl 2,4-dihydroxy-3-nitropyridine-5-carboxylate

ethyl 3-amino-2,4-dichloropyridine-5-carboxylate

ethyl 2,4-dichloro-3-nitropyridine-5-carboxylate

ethanol

Downstream raw materials:

ethyl 4-amino-6-chloro-5-fluoropyridine-3-carboxylate

2,4-dichloro-3-fluoropyridine-5-carboxylic acid