2-(4-(benzyloxy)phenyl)propan-2-ol

Base Information

• Chemical Name: 2-(4-(benzyloxy)phenyl)propan-2-ol
• CAS No.: 94571-13-8
• Molecular Formula: C16H18O2
• Molecular Weight: 242.318
• Mol file: 94571-13-8.mol

Synonyms:2-(4-(benzyloxy)phenyl)propan-2-ol;alpha,alpha-Dimethyl-4-(phenylmethoxy)benzenemethanol

Chemical Property of 2-(4-(benzyloxy)phenyl)propan-2-ol

Chemical Property:

• PSA: 29.46000
• Density: 1.092
• LogP: 3.49300

Purity/Quality:

98%Min ^*data from raw suppliers

alpha,alpha-Dimethyl-4-(phenylmethoxy)benzenemethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-(benzyloxy)phenyl)propan-2-ol

There total 2 articles about 2-(4-(benzyloxy)phenyl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

p-benzyloxyphenylbromide (6793-92-6) + acetone (67-64-1) → 1-methyl-1-<4-(benzyloxy)phenyl>ethanol (94571-13-8)

Guidance literature:

p-benzyloxyphenylbromide; With iodine; magnesium; In tetrahydrofuran; at 20 ℃; for 0.5h; Reflux; Inert atmosphere;

acetone; In tetrahydrofuran; for 3h; Reflux; Inert atmosphere;

Reference yield:

aq. sodium chloride + 4'-benzyloxy-acetophenone (54696-05-8) + ammonium chloride + methyl iodide (74-88-4) → 1-methyl-1-<4-(benzyloxy)phenyl>ethanol (94571-13-8)

Guidance literature:

With magnesium; In tetrahydrofuran; hexane; dichloromethane; tert-butyl methyl ether; ethyl acetate;

Reference yield: 83.0%

N-benzyloxyamine (622-33-3) + 1-methyl-1-<4-(benzyloxy)phenyl>ethanol (94571-13-8) → O-benzyl-N-<1-methyl-1-<4-(benzyloxy)phenyl>ethyl>hydroxylamine (118684-93-8)

Guidance literature:

With trifluoroacetic acid; In benzene; for 48h; Ambient temperature;

DOI:10.1021/jo00266a050

upstream raw materials:

4'-benzyloxy-acetophenone

methyl iodide

p-benzyloxyphenylbromide

acetone

Downstream raw materials:

O-benzyl-N-<1-methyl-1-<4-(benzyloxy)phenyl>ethyl>hydroxylamine

N-<1-methyl-1-<4-(benzyloxy)phenyl>ethyl>hydroxylamine

O-(tert-butyldiphenylsilyl)-N-<1-methyl-1-<4-(benzyloxy)phenyl>ethyl>hydroxylamine

(R)-4-(4-benzyloxy-phenyl)-1-(1-phenyl-ethyl)-1,2,3,6-tetrahydro-pyridine