Sildenafil EP IMpurity D

Base Information

• Chemical Name: Sildenafil EP IMpurity D
• CAS No.: 1357931-55-5
• Molecular Formula: C22H30N6O4S
• Molecular Weight: 392.436
• Mol file: 1357931-55-5.mol

Synonyms:Sildenafil EP IMpurity D;3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxybenzenesulfonic acid;Sildenafil impurity D

Chemical Property of Sildenafil EP IMpurity D

Chemical Property:

• PKA: -0.81±0.50(Predicted)
• PSA: 135.55000
• Density: 1.48±0.1 g/cm3(Predicted)
• LogP: 3.00230

Purity/Quality:

99%, ^*data from raw suppliers

DemethylpiperazinylSildenafilSulfonicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Demethylpiperazinyl Sildenafil Sulfonic Acid (Sildenafil EP Impurity D) is an impurity of Sildenafil citrate (S435000).

Technology Process of Sildenafil EP IMpurity D

There total 6 articles about Sildenafil EP IMpurity D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (139756-22-2) → 4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonic acid (1357931-55-5)

Guidance literature:

With ethanol; for 5h; Reagent/catalyst; Reflux;

Reference yield: 50.0%

viagra (139755-83-2) → 4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonic acid (1357931-55-5)

Guidance literature:

With sulfuric acid; water; at 20 - 100 ℃; for 41h;

Reference yield:

sildenafil citrate → 4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonic acid (1357931-55-5) + 5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one (139756-21-1) + 4-[(2-ethoxybenzoyl)amino]-1-methyl-3-propyl-1H-pyrazole-5-carboxamide (139756-03-9) + Desmethylsildenafil

Guidance literature:

With dihydrogen peroxide; In water; at 80 ℃; for 3h;

upstream raw materials:

5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

viagra

2-ethoxylbenzaldehyde

5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one

Downstream raw materials:

5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

viagra

5-[2-ethoxy-5-(4-ethylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

C₂₇H₃₂N₆O₄S

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