2-(4-Bromo-2-chlorophenyl)ethyl Iodide

Base Information

• Chemical Name: 2-(4-Bromo-2-chlorophenyl)ethyl Iodide
• CAS No.: 916516-91-1
• Molecular Formula: C8H7BrClI
• Molecular Weight: 345.405
• Mol file: 916516-91-1.mol

Synonyms:2-(4-Bromo-2-chlorophenyl)ethyl Iodide;4-BroMo-2-chloro-1-(2-iodoethyl)-benzene

Chemical Property of 2-(4-Bromo-2-chlorophenyl)ethyl Iodide

Chemical Property:

• PSA: 0.00000
• LogP: 4.08000
• Solubility.: Dichloromethane

Purity/Quality:

98% ^*data from raw suppliers

2-(4-Bromo-2-chlorophenyl)ethylIodide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Bromo-2-chlorophenyl)ethyl Iodide

There total 2 articles about 2-(4-Bromo-2-chlorophenyl)ethyl Iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-bromo-2-chlorophenyl)ethyl alcohol (916516-90-0) → 4-bromo-2-chloro-1-(2-iodoethyl)benzene (916516-91-1)

Guidance literature:

2-(4-bromo-2-chlorophenyl)ethyl alcohol; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 1h;

With sodium iodide; In butanone; at 81 ℃; for 1h;

Reference yield:

C9H10BrClO3S → 4-bromo-2-chloro-1-(2-iodoethyl)benzene (916516-91-1)

Guidance literature:

With sodium iodide; In butanone; Reflux;

DOI:10.1021/jm901776q

Reference yield:

4-bromo-2-chloro-1-(2-iodoethyl)benzene (916516-91-1) + (6R)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether (207923-14-6) → (2S,5R)-2-(4-bromo-2-chlorophenyl)ethyl-3,6-dimethoxy-2-methyl-5-isopropyl-2,5-dihydropyrazine (1260511-58-7)

Guidance literature:

(6R)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

4-bromo-2-chloro-1-(2-iodoethyl)benzene; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.5h;

upstream raw materials:

2-(4-bromo-2-chlorophenyl)ethyl alcohol

Downstream raw materials:

diethyl 2-[2-(4-bromo-2-chlorophenyl)ethyl]-2-(tert-butoxycarbonylamino)malonate

(2S,5R)-2-(4-bromo-2-chlorophenyl)ethyl-3,6-dimethoxy-2-methyl-5-isopropyl-2,5-dihydropyrazine

methyl (S)-4-(4-bromo-2-chlorophenyl)-2-t-butoxycarbonylamino-2-methyl butyrate

(S)-4-(4-bromo-2-chlorophenyl)-2-t-butoxycarbonylamino-2-methylbutan-1-ol

Refernces

• 1、 -. "2-AMINOBUTANOL COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES". Page/Page column 23. . Retrieved 2009/02/10.