(2S,5R)-2-(4-bromo-2-chlorophenyl)ethyl-3,6-dimethoxy-2-methyl-5-isopropyl-2,5-dihydropyrazine

Base Information

Chemical Name:(2S,5R)-2-(4-bromo-2-chlorophenyl)ethyl-3,6-dimethoxy-2-methyl-5-isopropyl-2,5-dihydropyrazine
CAS No.:1260511-58-7
Molecular Formula:C₁₈H₂₄BrClN₂O₂
Molecular Weight:415.758
Hs Code.:

Synonyms:(2S,5R)-2-(4-bromo-2-chlorophenyl)ethyl-3,6-dimethoxy-2-methyl-5-isopropyl-2,5-dihydropyrazine

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Chemical Property of (2S,5R)-2-(4-bromo-2-chlorophenyl)ethyl-3,6-dimethoxy-2-methyl-5-isopropyl-2,5-dihydropyrazine

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Technology Process of (2S,5R)-2-(4-bromo-2-chlorophenyl)ethyl-3,6-dimethoxy-2-methyl-5-isopropyl-2,5-dihydropyrazine

There total 1 articles about (2S,5R)-2-(4-bromo-2-chlorophenyl)ethyl-3,6-dimethoxy-2-methyl-5-isopropyl-2,5-dihydropyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 916516-91-1
4-bromo-2-chloro-1-(2-iodoethyl)benzene

: 207923-14-6
(6R)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether

: 1260511-58-7
(2S,5R)-2-(4-bromo-2-chlorophenyl)ethyl-3,6-dimethoxy-2-methyl-5-isopropyl-2,5-dihydropyrazine

Guidance literature:: (6R)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

4-bromo-2-chloro-1-(2-iodoethyl)benzene; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.5h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1260511-58-7
(2S,5R)-2-(4-bromo-2-chlorophenyl)ethyl-3,6-dimethoxy-2-methyl-5-isopropyl-2,5-dihydropyrazine

: 1260511-60-1
methyl (S)-4-(4-bromo-2-chlorophenyl)-2-t-butoxycarbonylamino-2-methyl butyrate

Guidance literature:: (2S,5R)-2-(4-bromo-2-chlorophenyl)ethyl-3,6-dimethoxy-2-methyl-5-isopropyl-2,5-dihydropyrazine; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

di-tert-butyl dicarbonate; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 1260511-58-7
(2S,5R)-2-(4-bromo-2-chlorophenyl)ethyl-3,6-dimethoxy-2-methyl-5-isopropyl-2,5-dihydropyrazine

: 1260511-77-0
(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-2-methylbutan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

1.2: 1 h / 20 °C

2.1: lithium borohydride; ethanol / tetrahydrofuran / 2 h / Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 3 h / Reflux; Inert atmosphere

With hydrogenchloride; lithium borohydride; ethanol; N-ethyl-N,N-diisopropylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 1,4-dioxane;