Rucaparib intermediate

Base Information

Chemical Name:Rucaparib intermediate
CAS No.:773059-19-1
Molecular Formula:C19H18FN3O.HCl
Molecular Weight:359.831
Hs Code.:
Mol file:773059-19-1.mol

Synonyms:Rucaparib intermediate;Rucaparib Phosphate Impurity;PF01367388 intermidiate;Rucaparib Hydrochloride;Desfluoro Rucaparib;8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-azepino[5,4,3-cd]indol-6-one monohydrochloride

Suppliers and Price of Rucaparib intermediate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Rucaparib intermediate

Chemical Property:

PSA：56.92000
LogP:4.50100

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Rucaparib intermediate

There total 10 articles about Rucaparib intermediate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 773059-19-1
8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one hydrochloride

Guidance literature:

Reference yield: 76.0%

: C₁₉H₁₆FN₃O

: 773059-19-1
8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one hydrochloride

: C₁₈H₁₅FN₂O₂

Guidance literature:: C₁₉H₁₆FN₃O; With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 3h; Large scale;

With hydrogenchloride; In tetrahydrofuran; methanol; water; for 1h; Large scale;

With pyrographite; In tetrahydrofuran; methanol; water; for 18h; Large scale;
DOI:10.1021/op200238p

Reference yield:

: 283173-84-2
4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd] indol-2-yl)-benzaldehyde

: 773059-19-1
8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one hydrochloride

: C₁₈H₁₅FN₂O₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; tetrahydrofuran; ethanol / 2 h / Large scale

2.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 - 20 °C / Large scale

2.2: 1 h / Large scale

2.3: 18 h / Large scale

With sodium tetrahydroborate; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/op200238p