3-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]-6-fluoro-1H-indole-4-carboxylic acid methyl ester

Base Information

Chemical Name:3-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]-6-fluoro-1H-indole-4-carboxylic acid methyl ester
CAS No.:1408282-25-6
Molecular Formula:C20H15FN2O4
Molecular Weight:366.349
Hs Code.:
Mol file:1408282-25-6.mol

Synonyms:3-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]-6-fluoro-1H-indole-4-carboxylic acid methyl ester;Rucaparib Impurity 4

Suppliers and Price of 3-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]-6-fluoro-1H-indole-4-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Ambeed
Methyl3-(2-(1,3-dioxoisoindolin-2-yl)ethyl)-6-fluoro-1H-indole-4-carboxylate 98%
1g
$ 766.00

Ambeed
Methyl3-(2-(1,3-dioxoisoindolin-2-yl)ethyl)-6-fluoro-1H-indole-4-carboxylate 98%
250mg
$ 256.00

Ambeed
Methyl3-(2-(1,3-dioxoisoindolin-2-yl)ethyl)-6-fluoro-1H-indole-4-carboxylate 98%
100mg
$ 166.00

Total 33 raw suppliers

Chemical Property of 3-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]-6-fluoro-1H-indole-4-carboxylic acid methyl ester

Chemical Property:

Boiling Point:579.4±50.0 °C(Predicted)
PKA:15.32±0.30(Predicted)
PSA：79.47000
Density:1.434±0.06 g/cm3(Predicted)
LogP:2.87020
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%, ^*data from raw suppliers

Methyl3-(2-(1,3-dioxoisoindolin-2-yl)ethyl)-6-fluoro-1H-indole-4-carboxylate 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]-6-fluoro-1H-indole-4-carboxylic acid methyl ester

There total 5 articles about 3-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]-6-fluoro-1H-indole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 2913-97-5
N-phthalimidyl-2-aminoacetaldehyde

: 1082040-43-4
6-fluoro-1H-indole-4-carboxylic acid methyl ester

: 1408282-25-6
3-(2-(phthalimido)ethyl)-6-fluoro-1H-indole-4-carboxylic acid methyl ester

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 8 - 20 ℃; for 90h;

Reference yield: 43.0%

: 2913-97-5
N-phthalimidyl-2-aminoacetaldehyde

: 1082040-43-4
6-fluoro-1H-indole-4-carboxylic acid methyl ester

: 3891-07-4
N-(2-Hydroxyethyl)phthalimide

: 1408282-25-6
3-(2-(phthalimido)ethyl)-6-fluoro-1H-indole-4-carboxylic acid methyl ester

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 - 30 ℃; for 28h; Large scale;
DOI:10.1021/op200238p

Reference yield:

: 33184-16-6
5-fluoro-2-methylbenzoic acid

: 1408282-25-6
3-(2-(phthalimido)ethyl)-6-fluoro-1H-indole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: nitric acid; sulfuric acid

2: triethylamine / N,N-dimethyl acetamide / 120 °C

3: palladium on activated charcoal; hydrogen; sodium acetate

4: triethylsilane; trifluoroacetic acid / dichloromethane

With triethylsilane; sulfuric acid; palladium on activated charcoal; hydrogen; nitric acid; sodium acetate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide;