AKOS BAR-2012

Base Information

Chemical Name:AKOS BAR-2012
CAS No.:769073-20-3
Molecular Formula:C14H15NO
Molecular Weight:213.279
Hs Code.:
Mol file:769073-20-3.mol

Synonyms:AKOS BAR-2012;4'-METHOXY-BIPHENYL-4-METHANAMINE;OTAVA-BB 1179173

Suppliers and Price of AKOS BAR-2012

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(4'-Methoxy-[1,1'-biphenyl]-4-yl)methanamine 95+%
5g
$ 713.00

American Custom Chemicals Corporation
(4'-METHOXY-[1,1'-BIPHENYL]-4-YL)METHANAMINE 95.00%
5MG
$ 503.99

Acrotein
4'-Methoxy-biphenyl-4-methanamine 97%
1g
$ 275.00

Total 3 raw suppliers

Chemical Property of AKOS BAR-2012

Chemical Property:

PSA：35.25000
LogP:3.52120

Purity/Quality:

98% ^*data from raw suppliers

(4'-Methoxy-[1,1'-biphenyl]-4-yl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4''-?Methoxy-[1,1''-biphenyl]?-?4-?methanamine is used to prepare biphenylmethyl urea derivatves as MCH-R1 antagonists for reatment of obesity. It is also used to synthesize the Pseudomonas aeruginosa virulence factor LasB inhibitors.

Technology Process of AKOS BAR-2012

There total 2 articles about AKOS BAR-2012 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 3959-07-7
4-Bromobenzylamine

: 5720-07-0
4-methoxyphenylboronic acid

: 769073-20-3
(4'-methoxy-4-biphenyl)methylamine

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile; for 8h; Heating;
DOI:10.1016/j.bmc.2007.02.049

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 104-86-9
4-chlorobenzylamine

: 769073-20-3
(4'-methoxy-4-biphenyl)methylamine

Guidance literature:: With palladium diacetate; 2-(di-tert-butyl-phosphino)-1-phenyl-1H-pyrrole; In water; at 100 ℃; for 4h; pH=2.5 - 8.5; Inert atmosphere;
DOI:10.1039/c7nj03567e

Reference yield: 40.0%

: 937724-02-2
[1-(4-methylbenzyl)-4-piperidinyl]acetaldehyde

: 769073-20-3
(4'-methoxy-4-biphenyl)methylamine

: 937724-04-4
(4'-methoxy-4-biphenylmethyl)-{2-[1-(4-methylbenzyl)-4-piperidinyl]ethyl}amine

Guidance literature:: [1-(4-methylbenzyl)-4-piperidinyl]acetaldehyde; (4'-methoxy-4-biphenyl)methylamine; With molecular sieve; In methanol; at 20 ℃; for 12h;

With sodium tris(acetoxy)borohydride; In methanol; at 20 ℃; Further stages.;
DOI:10.1016/j.bmc.2007.02.049