2-[2-(2',6'-DICHLORO-4'-HYDROXPHENYLAMINO)PHENYL]-N,N-DIMETHYLACETAMIDE

Base Information

• Chemical Name: 2-[2-(2',6'-DICHLORO-4'-HYDROXPHENYLAMINO)PHENYL]-N,N-DIMETHYLACETAMIDE
• CAS No.: 698357-45-8
• Molecular Formula: C16H16Cl2N2O2
• Molecular Weight: 339.221
• Mol file: 698357-45-8.mol

Synonyms:2-[2-(2',6'-DICHLORO-4'-HYDROXPHENYLAMINO)PHENYL]-N,N-DIMETHYLACETAMIDE;2-[(2,6-Dichloro-4-hydroxyphenyl)aMino]-N,N-diMethyl-benzeneacetaMide

Chemical Property of 2-[2-(2',6'-DICHLORO-4'-HYDROXPHENYLAMINO)PHENYL]-N,N-DIMETHYLACETAMIDE

Chemical Property:

• Melting Point: 237°C
• PSA: 52.57000
• LogP: 4.14630
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

2-[2-(2’,6’-Dichloro-4’-hydroxphenylamino)phenyl]-N,N-dimethylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[2-(2',6'-DICHLORO-4'-HYDROXPHENYLAMINO)PHENYL]-N,N-DIMETHYLACETAMIDE

There total 8 articles about 2-[2-(2',6'-DICHLORO-4'-HYDROXPHENYLAMINO)PHENYL]-N,N-DIMETHYLACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.3%

2-(2-(2,6-dichloro-4-ethoxyphenylamino)phenyl)-N,N-dimethylacetamide (1261451-23-3) → 2-[2-(2',6'-dichloro-4'-hydroxyphenylamino)phenyl]-N,N-dimethylacetamide (698357-45-8)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.5012/bkcs.2010.31.10.3007

Reference yield: 81.0%

2-[2-(2',6'-dichloro-4'-methoxyphenylamino)phenyl]-N,N-dimethylacetamide (698357-36-7) → 2-[2-(2',6'-dichloro-4'-hydroxyphenylamino)phenyl]-N,N-dimethylacetamide (698357-45-8)

Guidance literature:

With boron tribromide; In dichloromethane; 1,2-dichloro-ethane; at 20 ℃; for 1h;

DOI:10.1021/jm030891w

Reference yield:

p-benzoquinone oxime (637-62-7) → 2-[2-(2',6'-dichloro-4'-hydroxyphenylamino)phenyl]-N,N-dimethylacetamide (698357-45-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / HCl (gas) / diethyl ether / 1 h / -10 - 0 °C

2: 82 percent / K₂CO₃; CuI; Cu / toluene / 48 h / Heating

3: 81 percent / BBr₃ / CH₂Cl₂; 1,2-dichloro-ethane / 1 h / 20 °C

With hydrogenchloride; copper(l) iodide; boron tribromide; copper; potassium carbonate; In diethyl ether; dichloromethane; 1,2-dichloro-ethane; toluene; 2: Ullmann coupling;

DOI:10.1021/jm030891w

upstream raw materials:

2-[2-(2',6'-dichloro-4'-methoxyphenylamino)phenyl]-N,N-dimethylacetamide

o-iodophenylacetyl chloride

p-benzoquinone oxime

o-iodophenylacetic acid

Downstream raw materials:

4'-hydroxydiclofenac

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 698357-45-8 2-[2-(2',6'-DICHLORO-4'-HYDROXPHENYLAMINO)PHENYL]-N,N-DIMETHYLACETAMIDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send